Respiratory Training and Plasticity After Cervical Spinal Cord Injury.
Respiratory Training and Plasticity After Cervical Spinal Cord Injury.
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颈脊髓损伤后的呼吸训练和可塑性。
DOI：
10.3389/fncel.2021.700821
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发表时间：
2021
影响因子：
5.3
通讯作者：
Lane MA
中科院分区：
文献类型：
--
作者：
Randelman M;Zholudeva LV;Vinit S;Lane MA
虽然脊髓损伤（SCIs）导致大量的功能缺陷，其中许多是危及生命的，但大多数SCIs在解剖学上是不完整的。保留的神经通路有助于功能和解剖学上的神经可塑性，这种可塑性可以自发发生，也可以通过康复、电生理或药理策略加以利用。本文以颈椎脊髓损伤对呼吸网络的影响为重点，总结了非侵入性呼吸治疗如何利用这种神经可塑性潜能并增强长期恢复。特别关注目前临床使用的“呼吸训练”策略（例如，力量训练）和正在通过临床前和早期临床试验开发的策略[例如，通过改变吸入氧（缺氧）或二氧化碳刺激间歇性化学刺激]。还考虑了训练对非呼吸（如运动）网络的影响。本文综述了这一领域的临床前和转化研究进展，并展望了增强脊髓损伤后可塑性和改善功能预后的未来方向。
While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which are life threatening, the majority of SCIs are anatomically incomplete. Spared neural pathways contribute to functional and anatomical neuroplasticity that can occur spontaneously, or can be harnessed using rehabilitative, electrophysiological, or pharmacological strategies. With a focus on respiratory networks that are affected by cervical level SCI, the present review summarizes how non-invasive respiratory treatments can be used to harness this neuroplastic potential and enhance long-term recovery. Specific attention is given to “respiratory training” strategies currently used clinically (e.g., strength training) and those being developed through pre-clinical and early clinical testing [e.g., intermittent chemical stimulation via altering inhaled oxygen (hypoxia) or carbon dioxide stimulation]. Consideration is also given to the effect of training on non-respiratory (e.g., locomotor) networks. This review highlights advances in this area of pre-clinical and translational research, with insight into future directions for enhancing plasticity and improving functional outcomes after SCI.
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影响因子：
5.3
作者：
Christiansen, Lasse;Chen, Bing;Lei, Yuming;Urbin, M. A.;Richardson, Michael S. A.;Oudega, Martin;Sandhu, Milap;Rymer, W. Zev;Trumbower, Randy D.;Mitchell, Gordon S.;Perez, Monica A.
通讯作者：
Perez, Monica A.
影响因子：
4.2
作者：
Bonner, Joseph F.;Blesch, Armin;Neuhuber, Birgit;Fischer, Itzhak
通讯作者：
Fischer, Itzhak
影响因子：
3.3
作者：
Bach, KB;Mitchell, GS
通讯作者：
Mitchell, GS
影响因子：
4.2
作者：
Alvarez-Argote, Santiago;Gransee, Heather M.;Mantilla, Carlos B.
通讯作者：
Mantilla, Carlos B.
影响因子：
5.2
作者：
Dale-Nagle EA;Hoffman MS;MacFarlane PM;Satriotomo I;Lovett-Barr MR;Vinit S;Mitchell GS
通讯作者：
Mitchell GS