Numerical Simulation of a Nanoparticle Focusing Lens in a Microfluidic Channel by Using Immersed Finite Element Method
Numerical Simulation of a Nanoparticle Focusing Lens in a Microfluidic Channel by Using Immersed Finite Element Method
复制标题
DOI：
10.1166/jnn.2009.1787
复制
发表时间：
2009-12-01
影响因子：
--
通讯作者：
Kim, Young-Jin
中科院分区：
文献类型：
--
作者：
Lee, Tae-Rin;Chang, Yoon-Suk;Kim, Young-Jin
搭接芯片系统是纳米和生物工程领域具有挑战性的部分之一，例如，芯片上的微流体通道可用于选择目标颗粒和流体中生物分子的传质。然而，由于实验方法在时间和成本上都非常昂贵，因此需要替代的可靠方法来构想优化的通道。本研究的目的是从纳米颗粒控制的角度模拟微流体通道中的纳米颗粒聚焦透镜。一种有前途的浸入式有限元方法被扩展为估计通过聚焦透镜随机移动的纳米粒子的路径。假设通道流为不可压缩粘性流体，定量研究布朗运动效应以及颗粒的初始位置。作为代表性结果，当具有/不具有布朗运动的纳米粒子沿通道中心聚焦时，计算代表聚焦效率的集中因子。因此，预计新提出的考虑布朗运动的数值方法将在不久的将来有效地应用于包含各种颗粒、分子等的微流体通道的设计。
Lap-on-a-chip system is one of challenging parts in nano and bio engineering fields, for instance, microfluidic channels on the chip are useful for selecting a target particle and mass transferring of boiomolecules in fluid. However, since experimental approach is highly expensive both in time and cost, alternative reliable methods are required to conceive optimized channels. The purpose of this research is to simulate a nanoparticle focusing lens in a microfluidic channel from nanoparticle control point of view. A promising immersed finite element method is expanded to estimate the path of randomly moving nanoparticles through a focusing lens. The channel flow is assumed as incompressible viscous fluid and Brownian motion effects as well as initial position of particle are quantitatively examined. As a representative result, while the nanoparticles with/without Brownian motion were focused along the center of the channel, the concentration factor representing focusing efficiency was calculated. Therefore, it is expected that the newly proposed numerical method considering Brownian motion will be efficiently applicable to design the microfluidic channel containing various particles, molecules and so forth in the near future.