A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer.
A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer.
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DOI：
10.1177/0192623309351726
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发表时间：
2009-12
影响因子：
1.5
通讯作者：
Sills RC
中科院分区：
文献类型：
--
作者：
Hoenerhoff MJ;Hong HH;Ton TV;Lahousse SA;Sills RC
B6C3F1 小鼠、F344 大鼠和其他动物模型在暴露于各种化合物后的肿瘤反应提供了证据，表明暴露于这些或类似化合物的人可能有患癌症的风险。尽管啮齿动物和人类的肿瘤通常在形态上相似，但肿瘤发生的潜在机制通常是未知的，并且在物种之间可能有所不同。因此，如果了解分子发病机制，就可以更好地确定动物肿瘤反应与人类健康的相关性。导致癌变的潜在分子机制很复杂，涉及多种遗传和表观遗传事件以及其他因素。为了解决环境致癌物的分子发病机制，我们检查啮齿动物肿瘤（例如肺、结肠、乳腺、皮肤、脑、间皮瘤）中与人类癌症相关的癌症基因和表观遗传事件的变化。我们的 NTP 研究已经确定了化学诱导的啮齿动物肿瘤中的几种遗传改变，这些改变对人类癌症很重要。在啮齿类动物模型中，由于暴露于环境污染物、职业化学品和其他化合物而导致化学致癌作用发生这种变化，这进一步证明它们对人类健康具有潜在的风险。这些研究还强调了对化学诱导的啮齿动物肿瘤进行分子评估的重要性，为 NTP 评估的化合物提供更大的公共卫生意义。
Tumor response in the B6C3F1 mouse, F344 rat, and other animal models following exposure to various compounds provides evidence that people exposed to these or similar compounds may be at risk for developing cancer. Although tumors in rodents and humans are often morphologically similar, underlying mechanisms of tumorigenesis are often unknown and may be different between the species. Therefore, the relevance of an animal tumor response to human health would be better determined if the molecular pathogenesis were understood. The underlying molecular mechanisms leading to carcinogenesis are complex and involve multiple genetic and epigenetic events and other factors. To address the molecular pathogenesis of environmental carcinogens, we examine rodent tumors (e.g., lung, colon, mammary gland, skin, brain, mesothelioma) for alterations in cancer genes and epigenetic events that are associated with human cancer. Our NTP studies have identified several genetic alterations in chemically induced rodent neoplasms that are important in human cancer. Identification of such alterations in rodent models of chemical carcinogenesis caused by exposure to environmental contaminants, occupational chemicals, and other compounds lends further support that they are of potential human health risk. These studies also emphasize the importance of molecular evaluation of chemically induced rodent tumors for providing greater public health significance for NTP evaluated compounds.
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影响因子：
11.2
作者：
Datta, Sonal;Hoenerhoff, Mark J.;Dimri, Goberdhan P.
通讯作者：
Dimri, Goberdhan P.
DOI：
10.2165/00128072-200204080-00004
发表时间：
2002-01-01
期刊：
Paediatric drugs
影响因子：
--
作者：
Bhana, Nila;Ormrod, Douglas;Figgitt, David P
通讯作者：
Figgitt, David P
影响因子：
50.3
作者：
Bachoo, RM;Maher, EA;DePinho, RA
通讯作者：
DePinho, RA
影响因子：
3.8
作者：
Anna, CH;Iida, M;Devereux, TR
通讯作者：
Devereux, TR
影响因子：
10.5
作者：
Fisher, GH;Wellen, SL;Varmus, HE
通讯作者：
Varmus, HE