CIRCULATING INTEGRINS - ALPHA-5-BETA-1, ALPHA-6-BETA-4 AND MAC-1, BUT NOT ALPHA-3-BETA-1, ALPHA-4-BETA-1 OR LFA-1
CIRCULATING INTEGRINS - ALPHA-5-BETA-1, ALPHA-6-BETA-4 AND MAC-1, BUT NOT ALPHA-3-BETA-1, ALPHA-4-BETA-1 OR LFA-1
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DOI：
10.1002/j.1460-2075.1992.tb05068.x
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发表时间：
1992-02-01
期刊：
影响因子：
11.4
通讯作者：
BRETSCHER, MS
中科院分区：
文献类型：
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作者：
BRETSCHER, MS
α -5- β -1， α -6- β -4和Mac-1整合素都参与内吞周期。相比之下，在被检测的细胞系中，α -3- β -1、α -4- β -1和LFA-1的反应要慢得多，或者根本没有。这表明α -链似乎决定了整合素是否循环，α -5- β -1、α -6- β -4和Mac-1可以通过内吞作用和再循环被带到移动细胞的前沿。
The alpha-5-beta-1, alpha-6-beta-4 and Mac-1 integrins all participate in the endocytotic cycle. By contrast, alpha-3-beta-1, alpha-4-beta-1 and LFA-1 do so much more slowly, or not at all, in the cell lines examined. This indicates that the alpha-chains appear to determine whether an integrin cycles or not, and that alpha-5-beta-1, alpha-6-beta-4 and Mac-1 can be brought to the leading edge of a moving cell by endocytosis and recycling.