A brief review of bone adaptation to unloading.
A brief review of bone adaptation to unloading.
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DOI：
10.1016/s1672-0229(08)60016-9
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发表时间：
2008-03
影响因子：
9.5
通讯作者：
Yokota, Hiroki
中科院分区：
文献类型：
--
作者：
Zhang, Ping;Hamamura, Kazunori;Yokota, Hiroki
承重骨不断地调整其结构和功能以适应机械环境。通过常规运动负荷可以刺激骨骼形成并防止骨质流失，但通过卧床休息和石膏固定以及在太空飞行期间暴露在失重环境中的负荷会降低其质量和强度。为了阐明卸载驱动骨适应的机制，采用旋转细胞培养和后肢悬吊的方法进行了体外和体内的基础分析。本文主要从成骨细胞基因表达研究和后肢悬吊研究两个方面介绍了我们对太空失重条件下骨骼动态平衡的最新认识。现有的大多数数据表明，卸载与通过共同的信号通路加载具有相反的效果。然而，是否存在卸货(而不是卸货)独有的途径仍是一个问题。
Weight-bearing bone is constantly adapting its structure and function to mechanical environments. Loading through routine exercises stimulates bone formation and prevents bone loss, but unloading through bed rest and cast immobilization as well as exposure to weightlessness during spaceflight reduces its mass and strength. In order to elucidate the mechanism underlying unloading-driven bone adaptation, ground-based in vitro and in vivo analyses have been conducted using rotating cell culturing and hindlimb suspension. Focusing on gene expression studies in osteoblasts and hindlimb suspension studies, this minireview introduces our recent understanding on bone homeostasis under weightlessness in space. Most of the existing data indicate that unloading has the opposite effects to loading through common signaling pathways. However, a question remains as to whether any pathway unique to unloading (and not to loading) may exist.