The effects of basic fibroblast growth factor (bFGF) on the breaking strength of acute incisional wounds
The effects of basic fibroblast growth factor (bFGF) on the breaking strength of acute incisional wounds
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DOI：
10.1016/s0923-1811(02)00019-1
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发表时间：
2002-08-01
影响因子：
4.6
通讯作者：
Ono, I
中科院分区：
文献类型：
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作者：
Ono, I
许多研究人员报道了细胞因子对溃疡的影响。特别是慢性溃疡。然而，细胞因子对急性切口伤口的断裂强度、瘢痕质量等的长期影响尚未完全阐明。本研究比较了在兔背部皮肤全层切割伤中，用传统的止血剂或在止血剂的基础上加用碱性成纤维细胞生长因子（bFGF）治疗瘢痕的断裂强度。我们将bFGF用于在家兔背部造成的全层急性皮肤切口伤口。比较术后即刻用bFGF和常规敷料治疗的创面的抗折强度，并对术后7周的瘢痕情况进行长期随访。还对它们进行了组织病理学检查。在伤口闭合时施用bFGF，特别是每cm 1.0 μ g的量。从术后5周开始，与对照组相比，断裂强度显著增加。组织病理学检查显示，bFGF治疗组术后即刻血管化程度高，术后5周及以后胶原纤维呈水平排列，并呈剂量依赖性。该研究表明，从手术后5周起，与对照组相比，在伤口闭合托姆施用bFGF显著增加了断裂强度。bFGF的应用也改善了瘢痕的质量。通过检查的表面状况以及组织学评价的瘢痕宽度确定瘢痕状况。所以我们认为这种细胞因子在临床上可能非常有效。对于伤口愈合过程往往延迟的患者，例如老年患者，或者甚至对于具有正常伤口愈合潜力的患者，当推荐高断裂强度时，这可能尤其如此。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Many researchers have reported the effects of cytokines on ulcers. especially on chronic ulcers. However, the long-term influences of cytokines on acute incisional wounds with respect to breaking strength, quality of the scar etc, have not been elucidated completely. In the present study, the breaking strength of scars produced by full thickness incisional wounds of the skin created on backs of rabbits were compared when the wounds were treated by conventional suturing or with basic fibroblast growth factor (bFGF) in addition to suturing. We administered bFGF to full thickness acute incisional wounds of the skin created on backs of rabbits. The breaking strengths of wounds treated by conventional suturing and those treated with bFGF soon after the operation were compared as were the conditions of the scars after long-term follow up to 7 weeks. They were also examined histopathologically. Administration of bFGF at the time of wound closure, especially 1.0 mug in amount per cm. increased the breaking strength significantly compared to the control group from 5 weeks after the operation. Moreover, histopathological examination revealed that there was rich vascularization soon after the operation and an arrangement of collagen fibers which lenticulated horizontally from the 5th week and later after the operation in the bFGF treated groups in a dose dependent manner. This study demonstrates that administration of bFGF at the tome of wound closure significantly increased the breaking strength compared to the control group from 5 weeks after the operation. And the administration of bFGF also improved the quality of the scar. the condition of the scar by surface condition by inspection as well as the width of scar at histological evaluations. So we think this cytokine may be highly effective clinically. This may be especially true for patients whose wound healing process tends to be delayed such as aged patients or when high breaking strength is recommended even for patients with normal wound healing potential. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.