Antibacterial effects of carbon nanotubes: Size does matter
Antibacterial effects of carbon nanotubes: Size does matter
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DOI：
10.1021/la800951v
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发表时间：
2008-07-01
期刊：
影响因子：
3.9
通讯作者：
Elimelech, Menachem
中科院分区：
文献类型：
--
作者：
Kang, Seoktae;Herzberg, Moshe;Elimelech, Menachem
我们提供了第一个证据，证明碳纳米管（CNT）的尺寸（直径）是决定其抗菌作用的关键因素，并且可能的主要CNT细胞毒性机制是与CNT直接接触造成的细胞膜损伤。用表征良好的单壁碳纳米管（SWNTs）和多壁碳纳米管（MWNTs）进行的实验表明，SWNTs对细菌的毒性比MWNTs大得多。基因表达数据表明，在MWNTs和SWNTs的存在下，大肠杆菌表达高水平的应激相关基因产物，在SWNTs的存在下表达的数量和幅度要高得多。
We provide the first evidence that the size (diameter) of carbon nanotubes (CNTs) is a key factor governing their antibacterial effects and that the likely main CNT-cytotoxicity mechanism is cell membrane damage by direct contact with CNTs. Experiments with well-characterized single-walled carbon nanotubes (SWNTs) and multiwalled carbon nanotubes (MWNTs) demonstrate that SWNTs are much more toxic to bacteria than MWNTs. Gene expression data show that in the presence of both MWNTs and SWNTs, Escherichia coli expresses high levels of stress-related gene products, with the quantity and magnitude of expression being much higher in the presence of SWNTs.