Particulate matter and SARS-CoV-2: A possible model of COVID-19 transmission
Particulate matter and SARS-CoV-2: A possible model of COVID-19 transmission
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DOI：
10.1016/j.scitotenv.2020.141532
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发表时间：
2021-01-01
影响因子：
9.8
通讯作者：
Chuang, Hsiao-Chi
中科院分区：
文献类型：
--
作者：
Nguyen Thanh Tung;Cheng, Po-Ching;Chuang, Hsiao-Chi
2019冠状病毒病（COVID-19）是由严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）引起的急性呼吸道疾病，已迅速发展成为全球大流行病。这种疾病是一种高度传染性的新型冠状病毒，可以影响所有年龄段的人。先前的报告观察到，颗粒物（PM）提供了与病毒混合的平台（即，流感）。然而，PM在SARS-CoV-2传播中的作用仍不清楚。在本文中，我们认为PM作为SARS-CoV-2的“载体”发挥了直接作用。据报道，SARS-CoV-2对血管紧张素转换酶2（ACE 2）受体具有高亲和力。间接地，暴露于PM增加了肺中ACE 2的表达，这有助于SARS-CoV-2病毒粘附。因此，严重污染地区SARS-CoV-2的高风险可以通过PM引起的ACE 2上调来解释。PM可能是SARS-CoV-2感染的直接和间接传播模式。(C)2020爱思唯尔B. V.保留所有权利。
Coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly developed into a pandemic throughout the world. This disease is a highly infectious novel coronavirus and can affect people of all ages. Previous reports observed that particulate matter (PM) provided a platform for intermixing with viruses (i.e., influenza). However, the role of PM in SARS-CoV-2 transmission remains unclear. In this paper, we propose that PM plays a direct role as a "carrier" of SARS-CoV-2. SARS-CoV-2 is reported to have a high affinity for the angiotensin-converting enzyme 2 (ACE2) receptor. Indirectly, exposure to PM increases ACE2 expression in the lungs which facilitates SARS-CoV-2 viral adhesion. Thus, the high risk of SARS-CoV-2 in heavily polluted regions can be explained by upregulation of ACE2 caused by PM. PM could be both a direct and indirect transmission model for SARS-CoV-2 infection. (C) 2020 Elsevier B.V. All rights reserved.