Carrier-effect on palladium-catalyzed, nucleophilic 18F-fluorination of aryl triflates
Carrier-effect on palladium-catalyzed, nucleophilic 18F-fluorination of aryl triflates
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DOI：
10.1002/jlcr.2973
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发表时间：
2012-10-01
影响因子：
1.8
通讯作者：
Coenen, Heinz H.
中科院分区：
文献类型：
--
作者：
Cardinale, Jens;Ermert, Johannes;Coenen, Heinz H.
最近发表的一种以氟化铯为原料的钯催化制备氟代芳烃的方法作为放射性氟化的新替代方案引起了人们的兴趣。为了测试该方法，开发了用于合成 4-[18F]氟甲苯和 1-[18F]氟萘作为模型系统的合适方案。在不添加载体的条件下进行反应的可能性特别令人感兴趣。然而，人们发现该反应需要载体的存在，从而限制了该方法只能合成低比活度的放射性示踪剂。版权所有 (c) 2012 John Wiley & Sons, Ltd.
A recently published palladium-catalyzed preparation of fluoroarenes starting from caesium fluoride attracted interest as a new alternative for radiofluorination. To test this method, a suitable protocol for the synthesis of 4-[18F]fluorotoluene and 1-[18F]fluoronaphthalene as model systems has been developed. The possibility to perform the reaction under no-carrier-added condition was of special interest. It was found out, however, that the reaction requires the presence of carrier, thus limiting the method to syntheses of radiotracers with low specific activity. Copyright (c) 2012 John Wiley & Sons, Ltd.