Thymic tolerance as a key brake on autoimmunity.

Thymic tolerance as a key brake on autoimmunity.
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DOI:
10.1038/s41590-018-0128-9
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发表时间:
2018-07
期刊:
影响因子:
30.5
通讯作者:
Anderson MS
Anderson MS
中科院分区:
医学1区
文献类型:
--
作者:
Cheng M;Anderson MS

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虽然胸腺长期以来被认为是T细胞选择的关键器官,但将这些选择事件与人类自身免疫联系起来的复杂细节一直具有挑战性。在过去的二十年中,通过遗传学了解胸腺耐受机制在自身免疫中的作用取得了快速进展。在这里,我们回顾了一些最近的进展,在我们的理解关键胸腺耐受过程,是至关重要的预防自身免疫性疾病。
Although the thymus has long been recognized as a key organ for T cell selection, the intricate details linking these selection events to human autoimmunity have been challenging. Over the last two decades, there has been rapid progress in understanding the role of thymic tolerance mechanisms in autoimmunity through genetics. Here, we review some of the recent progress in our understanding of key thymic tolerance processes that are critical for preventing autoimmune disease.
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