Mi-2/NuRD complex making inroads into DNA-damage response pathway.
Mi-2/NuRD complex making inroads into DNA-damage response pathway.
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DOI：
10.4161/cc.9.11.11735
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Kumar R
中科院分区：
文献类型：
--
作者：
Li DQ;Kumar R
在真核细胞中，DNA包装成高度浓缩的染色质对基于DNA的过程提出了重大障碍。细胞使用两种主要策略，包括组蛋白修饰和ATP依赖性染色质重塑，以改变染色质结构，从而允许蛋白质因子进入核小体DNA。除了它们在转录中的作用，组蛋白修饰和几类ATP依赖性染色质重塑复合物在功能上与有效的DNA修复有关。Mi-2/核小体重构和组蛋白去乙酰化（NuRD）复合物具有独特的核小体重构和组蛋白去乙酰化活性，在转录调控中发挥重要作用。然而，Mi-2/NuRD复合物在DNA损伤反应中的作用至今仍未被探索。近年来的研究发现，作为Mi-2/NuRD复合物组成部分的转移相关蛋白1（metastasis-associated protein 1，MTA 1）成功地进入了DNA损伤反应通路，从而将Mi-2/NuRD复合物和DNA损伤反应这两个以前互不相关的研究领域联系起来。本文就组蛋白修饰和染色质重塑在DNA损伤修复中的作用进行综述，并探讨Mi-2/NuRD复合物在DNA损伤反应中的新作用。
In eukaryotic cells, packaging of DNA into highly condensed chromatin presents a significant obstacle to DNA-based processes. Cells use two major strategies including histone modifications and ATP-dependent chromatin remodeling to alter chromatin structure that allows protein factors to gain access to nucleosomal DNA. Beyond their well-established role in transcription, histone modifications and several classes of ATP-dependent chromatin-remodeling complex have been functionally linked to efficient DNA repair. Mi-2/nucleosome remodeling and histone deacetylation (NuRD) complex uniquely possess both nucleosome remodeling and histone deacetylation activities, which play a vital role in regulating transcription. However, the role of the Mi-2/NuRD complex in DNA damage response remains largely unexplored until now. Recent findings reveal that metastasis-associated protein 1 (MTA1), an integral component of the Mi-2/NuRD complex, has successfully made inroads into DNA damage response pathway, and thus, links two previously unconnected Mi-2/NuRD complex and DNA damage response research areas. In this review, we will summarize recent progress concerning the functions of histone modifications and chromatin remodeling in DNA repair, and discuss new role of Mi-2/NuRD complex in DNA damage response.
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