Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia
Seroprevalence of IgG antibodies to pertussis toxin in children and adolescents in Estonia
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DOI：
10.1016/j.vaccine.2014.07.066
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发表时间：
2014-09-15
期刊：
影响因子：
5.5
通讯作者：
Lutsar, Irja
中科院分区：
文献类型：
--
作者：
Jogi, Piia;Oona, Marje;Lutsar, Irja
背景和目标：尽管免疫覆盖率很高，加强剂量也很频繁，但爱沙尼亚百日咳的全国通报率一直在上升。2010年达到97110万的峰值，是自1962年以来的最高发病率（210/100，000）。我们的目的是测量受试者中百日咳毒素（PT）IgG型抗体的患病率，≥ 62.5 IU/mL被认为是9- 14岁儿童中过去一年中百日咳的暗示。抗PT-IgG的GMC为7.4 IU/mL（95% CI 6.9-8.0）。在总共1053份血清样本中，高抗体滴度>= 125 IU/mL和>= 62.5 IU/mL的血清比例最高的是在接种百日咳疫苗加强剂时的年龄：分别为7岁10.9%（95% CI 4.1-22.3）和2岁36.9%（95% CI 25.3-49.8）。大约一半的血清中有不可检测的抗PT IgG水平。血清采样前一年9- 14岁儿童百日咳杆菌感染的估计发病率为6.3%（95%CI 33-10.8），这至少比相关年份官方报告的百日咳发病率高60倍。在上次百日咳免疫接种时间不到一年的情况下，血清学方法不适合诊断百日咳。检测不到抗PT IgG水平的受试者比例相对较高，官方报告的百日咳病例率相对较低，表明抗体水平低并不一定表明缺乏保护。百日咳的估计发病率远高于官方报道的数字，这表明无症状/轻度B。百日咳感染仍未被发现和报告。(C)2014爱思唯尔有限公司版权所有。
Background and aims: Despite high immunisation coverage and frequent booster doses, the national notification rates of pertussis in Estonia have been increasing. The peak of 971100,000 was reached in 2010 which is the highest incidence rate since 1962 (210/100,000).We aimed to measure the prevalence of pertussis toxin (PT) IgG type antibodies in subjects of = 62.5 IU/mL was considered suggestive to pertussis in the last year among 9- to 14-year-olds.Results: The GMC of the anti-PT-IgG was 7.4 IU/mL (95% CI 6.9-8.0). In the total of 1053 serum samples, the highest proportion of sera with high antibody titres >= 125 IU/mL and >= 62.5 IU/mL were at the ages when pertussis vaccine boosters were given: 7 years 10.9% (95% CI 4.1-22.3) and 2 years 36.9% (95% CI 25.3-49.8), respectively. Approximately half of all sera had undetectable anti-PT IgG levels. The estimated incidence of Bordetella pertussis infection among 9- to 14-year-olds in the year before serum sampling was 6.3% (95% Cl 33-10.8), which is at least 60 times higher than the officially reported incidence of pertussis disease in respective years.Conclusions: The serologic method is not suitable for diagnosing pertussis in instances when the last pertussis immunisation was less than one year ago. The relatively high proportion of subjects with undetectable anti-PT IgG levels and the relatively low rate of officially reported pertussis cases suggest that low antibody levels do not necessarily indicate the absence of protection. The estimated incidence rate of pertussis is much higher than officially reported figures, which suggests that asymptomatic/mild B. pertussis infection remains unrecognised and unreported. (C) 2014 Elsevier Ltd. All rights reserved.