LIPID SWELLING AND LIPOSOME FORMATION MEDIATED BY ELECTRIC-FIELDS
LIPID SWELLING AND LIPOSOME FORMATION MEDIATED BY ELECTRIC-FIELDS
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DOI：
10.1016/0302-4598(88)80013-8
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发表时间：
1988-06-01
期刊：
影响因子：
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通讯作者：
ANGELOVA, MI
中科院分区：
文献类型：
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作者：
DIMITROV, DS;ANGELOVA, MI
电场可以诱导、促进或阻碍脂质膨胀和脂质体的形成。本文简要地讨论了直流磁场影响的理论和实验结果，并提出了交流磁场中金属电极和玻璃表面脂质膨胀和脂质体形成的新数据和估计，以及直流磁场中带正电的脂质混合物的膨胀。从这些结果可以得出四个基本结论：(1)交流电场可以诱导脂质体的形成，使脂质体在电极表面膨胀；(2)脂质结构在交流电场中的振动是由电渗透效应引起的；(3)在没有电场的情况下，带正电的脂质混合物在正极上比在负极上膨胀得快；(4)电场不影响玻璃表面的脂质膨胀和脂质体形成，即当脂质不放置在电极上时。脂质体形成和脂质膨胀的可能机制包括渗透、静电、双层、机电和线张力效应。
Electric fields can induce, facilitate or hinder lipid swelling and liposome formation. This paper briefly discusses theoretical and experimental results of the effects of dc fields, and presents new data and estimates for lipid swelling and liposome formation on metal electrodes and glass surfaces in ac fields and for swelling of positively charged lipid mixtures in dc fields. There are four basic conclusions from these results: (1) ac fields can induce liposome formation for lipids swelling on electrode surfaces; (2) the vibrations of lipid structures in ac fields are due to electro-osmotic effects; (3) positively charged lipid mixtures swell faster on the positive electrode than on the negative one and in the absence of a field; and (4) electric fields do not affect lipid swelling and liposome formation on glass surfaces, i.e. when the lipid is not placed on the very electrode. Possible mechanisms of liposome formation and lipid swelling include osmotic, electrostatic, double layer, electromechanical and line tension effects.