Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice
Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice
复制标题
DOI：
10.1128/iai.72.5.3077-3080.2004
复制
发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Pozzi, G
中科院分区：
文献类型：
--
作者：
Iannelli, F;Chiavolini, D;Pozzi, G
在小鼠感染模型中研究了肺炎链球菌表面蛋白C（PspC;也称为SpsA、CbpA和Hic）在肺炎链球菌脓毒症中的作用。在菌株D39（2型）和A66（3型）中缺失pspC基因，并通过静脉注射到小鼠中来测试突变体。感染突变株的动物存活率显著增加，50%致死剂量比野生型高250倍。我们的研究结果表明，PspC提供了一个决定性的贡献败血症的发展。
The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.