Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
Establishment of multiple sublineages of H5N1 influenza virus in Asia: Implications for pandemic control
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DOI：
10.1073/pnas.0511120103
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发表时间：
2006-02-21
影响因子：
11.1
通讯作者：
Guan, Y
中科院分区：
文献类型：
--
作者：
Chen, H;Smith, GJD;Guan, Y
防范高致病性禽流感A亚型H5 N1可能引起的流感大流行已成为全球优先事项。病毒传播到欧洲以及东南亚持续的人类感染加剧了对大流行的担忧。目前尚不清楚大流行毒株可能从何处出现;目前的注意力集中在越南、泰国，最近又集中在印度尼西亚和中国。在这里，我们报告说，遗传和抗原性不同的亚系H5 N1病毒已成为建立在家禽在东南亚不同的地理区域，表明该病毒的长期地方性，和分离的H5 N1病毒从明显健康的候鸟在中国南方。我们的数据显示，H5 N1流感病毒已继续从华南地区的既定来源通过家禽运输和鸟类迁徙传播到其他地区。查明各区域不同的亚系有助于了解H5 N1病毒持续存在和传播的机制，提供与控制家禽感染源直接相关的信息。它指出，监测的地理范围必须比以前设想的更广，并包括遗传和抗原多样性更大的H5 N1病毒。
Preparedness for a possible influenza pandemic caused by highly pathogenic avian influenza A subtype H5N1 has become a global priority. The spread of the virus to Europe and continued human infection in Southeast Asia have heightened pandemic concern. It remains unknown from where the pandemic strain may emerge; current attention is directed at Vietnam, Thailand, and, more recently, Indonesia and China. Here, we report that genetically and antigenically distinct sublineages of H5N1 virus have become established in poultry in different geographical regions of Southeast Asia, indicating the long-term endemicity of the virus, and the isolation of H5N1 virus from apparently healthy migratory birds in southern China. Our data show that H5N1 influenza virus, has continued to spread from its established source in southern China to other regions through transport of poultry and bird migration. The identification of regionally distinct sublineages contributes to the understanding of the mechanism for the perpetuation and spread of H5N1, providing information that is directly relevant to control of the source of infection in poultry. It points to the necessity of surveillance that is geographically broader than previously supposed and that includes H5N1 viruses of greater genetic and antigenic diversity.