Powder Micronization Using a CO2 Supercritical Antisolvent Type Process: Comparison of Different Introduction Devices
Powder Micronization Using a CO2 Supercritical Antisolvent Type Process: Comparison of Different Introduction Devices
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DOI：
10.1021/ie8017803
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发表时间：
2009-06-17
影响因子：
4.2
通讯作者：
Badens, Elisabeth
中科院分区：
文献类型：
--
作者：
Boutin, Olivier;Petit-Gas, Thomas;Badens, Elisabeth
超临界介质中的许多重结晶过程利用CO2作为抗溶剂。本文介绍了两种基于超临界反溶剂过程原理的引入装置：撞击射流和同心管反溶剂反应器。这两种方法开发起来非常简单，并且可以改善两相之间的混合。在10 MPa和308 K下，用L-聚乳酸进行了冲击射流实验，得到了平均直径为1.4 ~ 2.3 μ m的球形颗粒。对于同心管抗溶剂反应器，灰黄霉素在10 MPa和308和323 K之间的温度下进行测试，提供长度在25和50 μ m之间的针。这些结果与先前的结果相结合，允许将这些引入装置与经典的超临界抗溶剂（SAS）工艺进行比较，证明了以下改进：（i）减小粒度，（ii）增加初始溶质浓度，和（iii）工艺强化。
Many recrystallization processes in supercritical medium utilize CO2 as antisolvent. This work presents two introduction devices based on the principle of the supercritical antisolvent process: the impinging jets and the concentric tube antisolvent reactor. Those two processes are very simple to develop and allow improving the mixing between the two phases. Some experiments have been conducted for the impinging jets using L-polylactic acid at 10 MPa and 308 K giving spherical particles with average diameter varying from 1.4 to 2.3 mu m. For the concentric tube antisolvent reactor, griseofulvin was tested at 10 MPa and temperatures between 308 and 323 K providing needles with lengths between 25 and 50 mu m. These results combined with previous ones allow comparing these introduction devices with the classical supercritical antisolvent (SAS) process, demonstrating the following improvements: (i) reduction of particle size, (ii) increase in initial solute concentration, and (iii) process intensification.