Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects
Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects
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DOI：
10.1111/j.1440-1819.2009.01985.x
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发表时间：
2009-01-01
影响因子：
11.9
通讯作者：
Kunugi, Hiroshi
中科院分区：
文献类型：
--
作者：
Hashimoto, Ryota;Noguchi, Hiroko;Kunugi, Hiroshi
目的：dysbindin基因（dystrobrevin binding protein 1：DTNBP 1）是精神分裂症的易感基因。精神分裂症的易感基因被假设为至少部分通过影响认知表现来介导该疾病的易感性。本研究旨在探讨dysbindin基因与认知功能的关系。（rs 2619539：P1655），这是日本人群中精神分裂症的风险无关SNP，并在日本人群中的70名精神分裂症患者和165名健康志愿者中调查了记忆和智商。该SNP与韦氏记忆量表修订版（WMS-R）上的两个记忆量表（言语记忆和一般记忆）以及韦氏成人智力量表修订版（WAIS-R）的三个子类别（健康受试者的词汇，相似性和图片完成）相关。结论：DTNBP 1基因的一个风险独立的SNP可能对健康人的记忆和智商等认知功能有影响。
Aim: The dysbindin gene (dystrobrevin binding protein 1: DTNBP1) is a susceptibility gene for schizophrenia. Susceptibility genes for schizophrenia have been hypothesized to mediate liability for the disorder at least partly by influencing cognitive performance. This report investigated the relationship between cognitive function and the dysbindin gene.Methods: The possible association between a single nucleotide polymorphism (SNP) of DTNBP1 (rs2619539: P1655), which is a risk-independent SNP for schizophrenia in Japanese populations, and memory and IQ was investigated in 70 schizophrenia patients and 165 healthy volunteers in a Japanese population.Results: This SNP was associated with two memory scales, verbal memory and general memory, on the Wechsler Memory Scale-Revised (WMS-R), and three subcategories of the Wechsler Adult Intelligence Scale-Revised (WAIS-R), vocabulary, similarities and picture completion in healthy subjects. The SNP, however, did not influence either the indices of WMS-R, IQ or subcategories of WAIS-R in schizophrenia patients.Conclusion: A risk-independent SNP in DTNBP1 may have an impact on cognitive functions such as memory and IQ in healthy subjects.