Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice.
Adeno-associated virus-mediated knockdown demonstrates the major role of hepatic Bcrp in the overall disposition of the active metabolite of the tyrosine kinase inhibitor regorafenib in mice.
复制标题
腺相关病毒介导的敲除证明了肝脏 Bcrp 在小鼠体内酪氨酸激酶抑制剂瑞戈非尼活性代谢物的总体处置中的主要作用。
DOI:
10.1016/j.dmpk.2022.100483
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发表时间:
2023
期刊:
影响因子:
--
通讯作者:
Kato Y.
中科院分区:
文献类型:
--
作者:
Al-Shammari AH;Masuo Y;Yoshino S;Yamashita R;Ishimoto T;Fujita K;Kato Y.
影响因子:
3.9
作者:
Kitamura, Satoshi;Maeda, Kazuya;Sugiyama, Yuichi
通讯作者:
Sugiyama, Yuichi
影响因子:
4.7
作者:
B. Watkins;H. Esumi;K. Wakabayashi;M. Nagao;T. Sugimura
通讯作者:
T. Sugimura