Direct Reprogrammed Neuronal Cells as a Novel Resource for Cell Transplantation Therapy
Direct Reprogrammed Neuronal Cells as a Novel Resource for Cell Transplantation Therapy
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DOI：
10.3727/096368914x678274
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发表时间：
2014-05
影响因子：
3.3
通讯作者：
T. Yamashita;K. Abe
中科院分区：
文献类型：
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作者：
T. Yamashita;K. Abe
细胞移植/替代疗法作为治疗神经系统疾病如帕金森病、阿尔茨海默病和中风的新策略是有吸引力的。为了实现这种疗法，现在需要更安全和更有效的治疗细胞资源。由于诱导多能干细胞（induced pluripotent stem cells，iPSCs）在分化为多种细胞时能保持较高的复制能力和多能性，因此被认为是细胞移植治疗的一种有前景的细胞来源。然而，在临床应用中必须克服iPSC的高肿瘤发生率。最近的进展包括新的转录因子的组合，可以将体细胞转化为各种成熟的神经元细胞和神经干细胞，而不需要iPSC的命运。一些证据表明，这些直接诱导的神经元细胞几乎没有致瘤潜力。在本文中，我们讨论了这些细胞的优点，问题和临床应用的可能性细胞移植治疗。
Cell transplantation/replacement therapy is attractive as a novel strategy for neurological diseases such as Parkinson's disease, Alzheimer's disease, and stroke. To realize this therapy, safer and more therapeutic effective cell resources are now required. Since induced pluripotent stem cells (iPSCs) can retain high replication competence and pluripotency when they differentiate into various kinds of cells, they are regarded as a promising cell source for cell transplantation therapy. However, high tumorigenesis of iPSCs has to be overcome for clinical applications. Recent progress includes the combination of novel transcriptional factors that can convert somatic cells to various kinds of mature neuronal cells and neural stem cells without requiring iPSC fate. Some evidence indicates that these directly induced neuronal cells have little tumorigenic potential. In this article, we discuss the advantage, issues, and possibility of clinical application of these cells for cell transplantation therapy.