The impact of HIV central nervous system persistence on pathogenesis
The impact of HIV central nervous system persistence on pathogenesis
复制标题
艾滋病毒中枢神经系统持续存在对发病机制的影响
DOI：
10.1097/qad.0000000000002251
复制
发表时间：
2019-12-01
期刊：
影响因子：
3.8
通讯作者：
Barnes, Stephanie L.
中科院分区：
文献类型：
--
作者：
Brew, Bruce J.;Barnes, Stephanie L.
HIV在中枢神经系统中的持续存在是有争议的，特别是在联合抗逆转录病毒治疗抑制HIV病毒的背景下。此外，它的意义，在艾滋病毒相关的神经认知障碍，系统性艾滋病毒的发病机制，并在一般情况下，但特别是从大脑中根除艾滋病毒的发病机制，甚至更有争议。本综述将详细讨论每个方面，突出新的数据，特别是从最近的会议报告。
The persistence of HIV in the central nervous system is somewhat controversial particularly in the context of HIV viral suppression from combined antiretroviral therapy. Further, its significance in relation to HIV pathogenesis in the context of HIV-associated neurocognitive disorders, systemic HIV pathogenesis, and eradication in general, but especially from the brain, are even more contentious. This review will discuss each of these aspects in detail, highlighting new data, particularly from recent conference presentations.