Childhood Conscientiousness and Leukocyte Telomere Length 40 Years Later in Adult Women--Preliminary Findings of a Prospective Association.
Childhood Conscientiousness and Leukocyte Telomere Length 40 Years Later in Adult Women--Preliminary Findings of a Prospective Association.
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DOI：
10.1371/journal.pone.0134077
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Hampson SE
中科院分区：
文献类型：
--
作者：
Edmonds GW;Côté HC;Hampson SE
白细胞端粒长度（LTL）随着年龄的增长而缩短，是心血管疾病相关死亡率的一个前瞻性标志。许多健康行为和社会环境因素已被发现与LTL有关。其中几个也与任性有关，这是一种性格特征。责任心是一种有计划的倾向，坚持社会规范，并抑制pre-potent反应。与LTL一样，尽责性与死亡率存在前瞻性相关，可能是通过多种途径对生命过程中的健康产生累积影响。因此，我们假设儿童时期的焦虑水平可以预测成年后的LTL。我们在夏威夷人格与健康队列中选择了60名女性作为样本，其中30名被老师描述为童年时期的高责任感，30名被描述为低责任感。40年后成年时收集的干血斑样本用作LTL分析的DNA来源。尽责性与LTL较长相关（p = .02）。控制年龄并不能解释这种关联。控制教育和生理失调部分减弱了这种关联，当考虑到不同文化群体的LTL差异时，这种影响仍然显着。这些结果代表了第一个证据表明，童年的性格前瞻性地预测LTL 40年后在成年。我们的研究结果将是一致的中介假设，即幸福预测的生活路径和轨迹的健康，反映在利率的LTL侵蚀整个生命周期。
Leukocyte telomere length (LTL) shortens with age, and is a prospective marker of mortality related to cardiovascular disease. Many health behaviors and social environmental factors have been found to be associated with LTL. Several of these are also associated with conscientiousness, a dispositional personality trait. Conscientiousness is a propensity to be planful, adhere to social norms, and inhibit pre-potent responses. Like LTL, conscientiousness is prospectively related to mortality, possibly through cumulative effects on health over the life course via multiple pathways. As a result, we hypothesized that childhood levels of conscientiousness would predict LTL prospectively in adulthood. We selected a sample of 60 women in the Hawaii Personality and Health Cohort; 30 described by their teachers as high on conscientiousness in childhood and 30 described as low on the trait. Dried blood spot samples collected in adulthood 40 years later were used as sources of DNA for the LTL assay. Conscientiousness was associated with longer LTL (p = .02). Controlling for age did not account for this association. Controlling for education and physiological dysregulation partially attenuated the association, and the effect remained significant when accounting for differences in LTL across cultural groups. These results represent the first evidence that childhood personality prospectively predicts LTL 40 years later in adulthood. Our findings would be consistent with a mediation hypothesis whereby conscientiousness predicts life paths and trajectories of health that are reflected in rates of LTL erosion across the lifespan.