An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients.
An inverse association between serum soluble receptor of advanced glycation end products and hyperandrogenism and potential implication in polycystic ovary syndrome patients.
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晚期糖基化终产物的血清可溶性受体与高雄激素血症之间的负相关及其对多囊卵巢综合征患者的潜在影响
DOI：
10.1186/s12958-017-0227-8
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发表时间：
2017-01-26
期刊：
影响因子：
--
通讯作者：
Liu W
中科院分区：
文献类型：
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作者：
Liao Y;Huang R;Sun Y;Yue J;Zheng J;Wang L;Tao T;Ma J;Li S;Liu W
研究发现AGE-RAGE系统与多囊卵巢综合征（PCOS）的两个核心病理生理过程——胰岛素抵抗和高雄激素血症密切相关。本研究旨在探讨育龄PCOS患者晚期糖基化终末产物/晚期糖基化终末产物可溶性受体(AGEs/sRAGE)与人体测量、稳态模型评估-胰岛素抵抗(HOMA-IR)、游离雄激素指数(FAI)之间的关系。 148 名患有 PCOS 的中国女性参与了这项研究。根据体重指数（BMI）、腰围（WC）、HOMA-IR四分位数区间和雄激素水平划分亚组。通过 Pearson 相关分析评估 AGEs/sRAGE 与上述临床标志物之间的关系。血清AGEs随BMI、WC呈逐渐升高趋势。正常体重组（BMI< 24 kg/m2）与肥胖组（BMI≥28 kg/m2）之间达到统计学显着性。 sRAGE水平分别随着BMI、WC、HOMA-IR和FAI的增加而逐渐降低。此外，各组之间的差异具有统计学意义。相关分析显示BMI与血清AGEs水平呈正相关。相反，sRAGE水平与BMI、WC、HOMA-IR和FAI呈显着负相关。根据 ROC 曲线分析，存在胰岛素抵抗的 sRAGE 最佳点为 704.097 pg/ml。随着体内脂肪的积累，肥胖PCOS患者血清AGEs水平升高，而sRAGE水平降低。 sRAGE（一种诱饵受体）的血清水平在胰岛素抵抗状态较严重和 FAI 较高的患者中显着降低，这可能是治疗 PCOS（尤其是肥胖受试者）的潜在生物标志物和有希望的治疗靶点。
Studies found that AGE-RAGE system is closely related to insulin resistance and hyperandrogenemia, which are two core pathophysiological processes in polycystic ovary syndrome (PCOS). This study is to investigate the relationship among advanced glycation end-products/soluble receptor of advanced glycation end-products (AGEs/sRAGE) and anthropometric evaluation, homeostatic model assessment-insulin resistance (HOMA-IR), free androgen index (FAI) in reproductive-aged PCOS patients. One hundred and forty-eight Chinese women with PCOS were enrolled in this study. Subgroups were divided according to body mass index (BMI), waist circumference (WC), quartile intervals of HOMA-IR and androgen levels. The relationships between AGEs/sRAGE and above clinical markers were assessed by Pearson’s correlation analyses. Serum AGEs showed a gradually increased tendency with BMI and WC. It reached statistical significant between the normal weight group (BMI < 24 kg/m2) and the obesity group (BMI ≥ 28 kg/m2) . The sRAGE levels gradually decreased with increasing BMI, WC, HOMA-IR and FAI respectively. Furthermore, the differences between each group were statistical significant. The correlation analysis showed a positive correlation between BMI and serum AGEs levels. On the contrary, the sRAGE levels showed significantly inverse correlations with BMI, WC, HOMA-IR and FAI. The optimal point of sRAGE for the presence of insulin resistance was 704.097 pg/ml by ROC curve analysis. Along with the body fat accumulation, the serum levels of AGEs were increased, whereas, the serum levels of sRAGE were reduced in obese PCOS patients. The serum levels of sRAGE, which is a decoy receptor, dramatically decreased in the patients with more severe insulin resistant states and higher FAI, which might be a potential biomarker and a promising therapeutic target in the treatment of PCOS, especially in obese subjects.