The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007
The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from 2006 to 2007
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DOI：
10.1016/j.virusres.2008.07.015
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发表时间：
2008-11-01
期刊：
影响因子：
5
通讯作者：
Wu, Ho-Sheng
中科院分区：
文献类型：
--
作者：
Huang, Yuan-Pin;Lin, Tsuey-Li;Wu, Ho-Sheng
肠病毒（ev）是人类最常见的病原体之一。EV71感染在全球儿童中造成了与肠道病毒相关的毁灭性后果。本研究选取2006-2007年台湾地区11株EV71分离株进行n端VP1基因分析。对VP1基因403 bp的片段进行了测序，并进行了系统发育分析。此外，对两个分离株进行了全基因组测序。结果表明，B5和C5亚基因群在2年内在台湾流行并形成优势。此外，基因组B在VP1上的43位谷氨酸和58位苏氨酸是保守的，而基因组c则分别被赖氨酸和丙氨酸取代。据我们所知，这是台湾首次报道这两个EV71亚基因群的循环。(c) 2008年Elsevier B.V.出版
Enteroviruses (EVs) are among the most common pathogens in humans. EV71 infections have caused devastating enterovirus-associated outcomes in children globally. In this study, eleven EV71 isolates in Taiwan during 2006-2007 were selected for N-terminal VP1 gene analysis. A fragment of 403 bp on VP1 gene was sequenced and a phylogenetic analysis was performed. In addition, the full-length genome sequencing was carried out on two selected isolates. The results showed that subgenogroups of B5 and C5 had circulated and become predominant in Taiwan over the specified 2 years. Moreover, glutamic acid and threonine are found conservative at positions 43 and 58 on VP1 for genogroup B: however they are replaced by lysine and alanine, respectively, for genogroup C. To our knowledge, this is the first report describing the circulation of these two EV71 subgenogroups in Taiwan. (c) 2008 Published by Elsevier B.V.