Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors
Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors
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DOI：
10.1038/npp.2012.235
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发表时间：
2013-03
影响因子：
7.6
通讯作者：
A. Pushparaj;C. Hamani;W. Yu;Damian S Shin;Bin Kang;J. Nobrega;B. Foll
中科院分区：
文献类型：
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作者：
A. Pushparaj;C. Hamani;W. Yu;Damian S Shin;Bin Kang;J. Nobrega;B. Foll
颗粒岛叶皮质的药理学失活能够阻止大鼠的尼古丁摄取和寻求行为。在这项研究中，我们探索了使用电刺激调节岛区活动的潜力。训练动物在固定比例 5 (FR-5) 强化方案和渐进比例 (PR) 方案下自行施用尼古丁（每次输注 0.03 毫克/千克）。对 FR-5 和 PR 方案下的尼古丁自我给药以及尼古丁相关提示或尼古丁启动注射诱导的尼古丁寻求行为的恢复进行了岛区刺激效果的评估。还在含有岛状神经元的脑切片中检查了刺激的效果。在两种强化方案下，刺激显着减弱了尼古丁的摄入，以及由提示和启动引起的尼古丁寻求行为。这些影响似乎是尼古丁相关行为所特有的，因为刺激对进食行为没有任何影响。它们在解剖学上似乎是特定的，因为岛叶周围的刺激对行为没有影响。研究发现，刺激包含岛叶区域的脑切片可以使岛叶神经元失活。我们的结果表明，应进一步探索调节岛叶活动的深部脑刺激。
Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and-seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.