CELL-CYCLE CONTROL BY TIMER AND SIZER IN CHLAMYDOMONAS
CELL-CYCLE CONTROL BY TIMER AND SIZER IN CHLAMYDOMONAS
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DOI：
10.1038/304630a0
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发表时间：
1983-01-01
期刊：
影响因子：
64.8
通讯作者：
JOHN, PCL
中科院分区：
文献类型：
--
作者：
DONNAN, L;JOHN, PCL
细胞周期控制机制的保守性由不相关酵母中功能同源的分裂控制基因的存在和癌基因的非特异性作用2，3表示，但仍不确定生长细胞的什么性质导致分裂事件的发生。对临界尺寸的响应由分裂前较小细胞的较长生长期表示4 -6，这与分裂事件的延迟一致，直到达到最小尺寸;然而，在相同的细胞类型中，生长较快的细胞较大7 - 9，如果分裂遵循一个时间段，在此期间生长较快的细胞生长得更多，这更容易解释，正如哺乳动物细胞所假设的那样10 -11。因此，时间或大小依赖性控制可能是唯一重要的机制12，13;然而，我们在这里报告，这两种控制在衣原体分泌中确实起作用，因为周期持续时间是在计时器控制下，细胞大小决定了每个周期结束时的分裂轮次数，因此是否形成2，4，8或16个子细胞。
Conservation of cell cycle control mechanisms is indicated by the presence of functionally homologous division control genes in unrelated yeasts1and by the nonspecific action of oncogenes2,3, but it remains uncertain what property of a growing cell results in the initiation of events leading to division. Response to a critical size is indicated by the longer growth period of smaller cells prior to division4–6, which is consistent with deferment of division events until a minimum size is attained; however, in the same cell types faster growing cells are larger7–9and this is more easily explained if division follows a timed period during which faster growing cells grow more, as is postulated for mammalian cells10–11. Therefore, either time-or size-dependent controls might be the sole significant mechanism12,13; we report here, however, that both controls do function inChlamydomonassince cycle duration is under timer control and cell size determines the number of division rounds committed at the end of each cycle, and hence whether 2, 4, 8 or 16 daughter cells are formed.