Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis
Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis
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DOI：
10.3945/ajcn.111.027284
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发表时间：
2012-03-01
影响因子：
7.1
通讯作者：
Modi, Neena
中科院分区：
文献类型：
--
作者：
Gale, Chris;Logan, Karen M.;Modi, Neena
背景：早期营养可能会影响以后的身体组成。母乳喂养和配方奶粉喂养对婴儿身体成分的影响尚不确定。目的：我们对研究进行了系统回顾和荟萃分析，这些研究检查了健康足月婴儿的身体成分与母乳喂养或配方奶粉喂养的关系。设计：在PubMed中搜索人类研究，这些研究报告了母乳喂养和配方奶粉喂养婴儿的无脂肪质量、脂肪质量或脂肪质量百分比。手动检索参考文献，并联系作者获取更多数据。研究的质量进行了评估。喂养组之间的结果的差异进行了比较，在预先指定的年龄，使用固定效应分析，除了当异质性表明使用随机效应analysis.Results：我们确定了15项研究纳入系统评价和11项研究纳入荟萃分析。在配方奶粉喂养的婴儿中，3-4个月时的去脂体重较高[平均差异（95% CI）：0.13 kg（0.03，0.23 kg）]，8-9个月[0.29 kg（0.09，0.49 kg）]和12个月[0.30 kg（0.13，0.48 kg）]，3-4个月[-0.09 kg（-0.18，-0.01 kg）]和6个月[-0.18 kg（-0.34，-0.01 kg）]的脂肪量低于母乳喂养的婴儿。相反，在12个月时，配方奶粉喂养的婴儿的脂肪量高于母乳喂养的婴儿[0.29 kg（-0.03，0.61 kg）]。结论：与母乳喂养相比，配方奶粉喂养与婴儿期身体成分的改变有关。美国临床营养杂志2012;95：656-69。
Background: Early-life nutrition may influence later body composition. The effect of breastfeeding and formula feeding on infant body composition is uncertain.Objective: We conducted a systematic review and meta-analysis of studies that examined body composition in healthy, term infants in relation to breastfeeding or formula feeding.Design: PubMed was searched for human studies that reported the outcomes fat-free mass, fat mass, or the percentage of fat mass in breastfed and formula-fed infants. Bibliographies were hand searched, and authors were contacted for additional data. The quality of studies was assessed. Differences in outcomes between feeding groups were compared at prespecified ages by using fixed-effects analyses except when heterogeneity indicated the use of random-effects analyses.Results: We identified 15 studies for inclusion in the systematic review and 11 studies for inclusion in the meta-analysis. In formula-fed infants, fat-free mass was higher at 3-4 mo [mean difference (95% CI): 0.13 kg (0.03, 0.23 kg)], 8-9 mo [0.29 kg (0.09, 0.49 kg)], and 12 mo [0.30 kg (0.13, 0.48 kg)], and fat mass was lower at 3-4 mo [-0.09 kg (-0.18, -0.01 kg)] and 6 mo [-0.18 kg (-0.34, -0.01 kg)] than in breastfed infants. Conversely, at 12 mo, fat mass was higher in formula-fed infants [0.29 kg (-0.03, 0.61 kg)] than in breastfed infants.Conclusion: Compared with breastfeeding, formula feeding is associated with altered body composition in infancy. Am J Clin Nutr 2012;95:656-69.