Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase.
Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase.
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通过C-Jun N末端激酶对ENT1表达和ENT1依赖性核苷转运的调节。
DOI：
10.1016/j.bbrc.2010.11.125
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发表时间：
2011-01-07
影响因子：
3.1
通讯作者：
Graves LM
中科院分区：
文献类型：
--
作者：
Leisewitz AV;Zimmerman EI;Huang M;Jones SZ;Yang J;Graves LM
Equilibrative Nucleoside Transporters (ENTs) are facilitative transporters broadly selective for pyrimidine and purine nucleosides and are essential for the modulation of nucleoside concentration and nucleoside analog availability. Resistance to nucleoside-derived drugs strongly correlates with a deficiency of ENT1 expression in several tumor cells. Thus, it is crucial to understand the mechanisms by which this transporter is modulated. Using a mouse myeloid leukemic cell line as a model, we investigated whether stress-activated kinases regulate ENT1 expression and function. JNK activation, but not p38 MAPK results in rapid loss of mENT1 function, mRNA expression and promoter activity. c-Jun but not the mutant c-Jun Ser63/73Ala, decreased mENT1 promoter activity. Moreover cJun bound to an AP-1 site identified at −1196 of the promoter, suggesting a specific role for this transcription factor in mENT1 regulation. We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance.
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影响因子：
11.2
作者：
Cai, Jie;Damaraju, Vijaya L.;Gros, Philippe
通讯作者：
Gros, Philippe
影响因子：
5.5
作者：
Soler, C;Felipe, A;Pastor-Anglada, M
通讯作者：
Pastor-Anglada, M
影响因子：
4.8
作者：
MacKeigan, JP;Collins, TS;Ting, JPY
通讯作者：
Ting, JPY
DOI：
10.1124/jpet.102.044214
发表时间：
2003-02-01
影响因子：
3.5
作者：
Huang, M;Wang, YH;Graves, LM
通讯作者：
Graves, LM
影响因子：
1.3
作者：
Leisewitz, Andrea V.;Zimmerman, Eric I.;Graves, Lee M.
通讯作者：
Graves, Lee M.