Decoding locomotion from population neural activity in moving C. elegans.
Decoding locomotion from population neural activity in moving C. elegans.
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DOI：
10.7554/elife.66135
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发表时间：
2021-07-29
期刊：
影响因子：
7.7
通讯作者：
Leifer AM
中科院分区：
文献类型：
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作者：
Hallinen KM;Dempsey R;Scholz M;Yu X;Linder A;Randi F;Sharma AK;Shaevitz JW;Leifer AM
我们研究了秀丽隐杆线虫运动的神经表征通过记录种群钙活动在运动。我们报告说，群体活动比任何单个神经元更准确地解码运动。相关信号分布在具有不同运动调谐的神经元之间。两个截然不同的亚群对解码速度和曲率提供了信息，不同的神经元活动提供了与行为的不同方面或行为母题的不同实例相关的特征。为了验证我们的测量结果，我们标记了神经元AVAL和AVAR，发现它们的活动在向后运动时表现出预期的瞬态。最后，我们比较了移动和静止期间的种群活动。固定改变了神经活动的相关结构及其动力学。运动时与AVA正相关的神经元在静止时变为负相关，反之亦然。这项工作提供了必要的实验测量，为了解秀丽隐杆线虫运动背后的种群动态提供了信息和限制。
We investigated the neural representation of locomotion in the nematode C. elegans by recording population calcium activity during movement. We report that population activity more accurately decodes locomotion than any single neuron. Relevant signals are distributed across neurons with diverse tunings to locomotion. Two largely distinct subpopulations are informative for decoding velocity and curvature, and different neurons’ activities contribute features relevant for different aspects of a behavior or different instances of a behavioral motif. To validate our measurements, we labeled neurons AVAL and AVAR and found that their activity exhibited expected transients during backward locomotion. Finally, we compared population activity during movement and immobilization. Immobilization alters the correlation structure of neural activity and its dynamics. Some neurons positively correlated with AVA during movement become negatively correlated during immobilization and vice versa. This work provides needed experimental measurements that inform and constrain ongoing efforts to understand population dynamics underlying locomotion in C. elegans.