Matrix Metalloproteinase 1 in Pre-eclampsia and Fetal Growth Restriction: Reduced Gene Expression in Decidual Tissue and Protein Expression in Extravillous Trophoblasts
Matrix Metalloproteinase 1 in Pre-eclampsia and Fetal Growth Restriction: Reduced Gene Expression in Decidual Tissue and Protein Expression in Extravillous Trophoblasts
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DOI：
10.1016/j.placenta.2010.04.003
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发表时间：
2010-07-01
期刊：
影响因子：
3.8
通讯作者：
Austgulen, R.
中科院分区：
文献类型：
--
作者：
Lian, I. A.;Toft, J. H.;Austgulen, R.
绒毛外滋养细胞（EVT）的浅表侵袭和螺旋动脉重塑受损是妊娠合并先兆子痫（PE）和胎儿生长受限（FGR）的特征性现象。然而，根本原因仍不清楚。在这项研究中，通过 Affymetrix HG Focus 微阵列评估了患有 PE 和/或 FGR 的妊娠 (n = 18) 和正常妊娠 (n = 17) 的蜕膜基底组织中的基因表达，以获得发病机制的线索。以错误发现率 (FDR) 检测到总共 200 个差异表达转录本
Superficial invasion of extravillous trophoblasts (EVTs) and impaired spiral artery remodelling are characterizing phenomena in pregnancies complicated by pre-eclampsia (PE) and fetal growth restriction (FGR). However, the underlying causes remain unclear. In this study, gene expression in decidua basalis tissue from pregnancies complicated with PE and/or FGR (n = 18) and normal pregnancies (n = 17) was assessed by Affymetrix HG Focus microarray to obtain hints of mechanisms involved in the pathogenesis. A total of 200 differentially expressed transcripts were detected at a false discovery rate (FDR)