Impact of postprandial glycaemia on health and prevention of disease.
Impact of postprandial glycaemia on health and prevention of disease.
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DOI：
10.1111/j.1467-789x.2012.01011.x
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发表时间：
2012-10
期刊：
影响因子：
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通讯作者：
Vinoy S
中科院分区：
文献类型：
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作者：
Blaak EE;Antoine JM;Benton D;Björck I;Bozzetto L;Brouns F;Diamant M;Dye L;Hulshof T;Holst JJ;Lamport DJ;Laville M;Lawton CL;Meheust A;Nilson A;Normand S;Rivellese AA;Theis S;Torekov SS;Vinoy S
餐后血糖，以及相关的高胰岛素血症和脂血症，与慢性代谢性疾病如肥胖、2型糖尿病（T2DM）和心血管疾病（CVD）的发展有关。在这篇综述中，现有的证据讨论了餐后血糖与体重控制、氧化应激、T2DM和CVD的发展以及保持最佳运动和认知表现的关系。有机制证据表明餐后血糖或血糖变异性与这些疾病的发展或认知和运动表现的损害有关。然而，餐后血糖与许多其他（危险）因素以及空腹血糖有关。在许多研究中，与膳食相关的血糖反应没有得到充分的表征，或者描述食物或膳食成分的方法，或者餐后血糖测量的持续时间有限。很明显，为了对餐后血糖与健康和疾病的关系得出更明确的结论，有必要进行更多的随机对照饮食干预试验，使用有效的低糖和高糖反应饮食。同样重要的是评估餐后血糖的时间过程的潜在作用。
Postprandial glucose, together with related hyperinsulinemia and lipidaemia, has been implicated in the development of chronic metabolic diseases like obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In this review, available evidence is discussed on postprandial glucose in relation to body weight control, the development of oxidative stress, T2DM, and CVD and in maintaining optimal exercise and cognitive performance. There is mechanistic evidence linking postprandial glycaemia or glycaemic variability to the development of these conditions or in the impairment in cognitive and exercise performance. Nevertheless, postprandial glycaemia is interrelated with many other (risk) factors as well as to fasting glucose. In many studies, meal-related glycaemic response is not sufficiently characterized, or the methodology with respect to the description of food or meal composition, or the duration of the measurement of postprandial glycaemia is limited. It is evident that more randomized controlled dietary intervention trials using effective low vs. high glucose response diets are necessary in order to draw more definite conclusions on the role of postprandial glycaemia in relation to health and disease. Also of importance is the evaluation of the potential role of the time course of postprandial glycaemia.