B-LYMPHOTROPIC PAPOVAVIRUS AND POSSIBILITY OF INFECTIONS IN HUMANS
B-LYMPHOTROPIC PAPOVAVIRUS AND POSSIBILITY OF INFECTIONS IN HUMANS
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DOI：
10.1002/jmv.1890060405
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发表时间：
1980-01-01
影响因子：
12.7
通讯作者：
HAUSEN, HZ
中科院分区：
文献类型：
--
作者：
BRADE, L;MULLERLANTZSCH, N;HAUSEN, HZ
乳多空病毒组的一个新成员是从 EBV[Epstein-Barr 病毒] 转化的非洲绿猴 (AGM) B 淋巴细胞中分离出来的。该病毒以其B淋巴细胞宿主范围为特征，暂时命名为嗜淋巴细胞乳头多空病毒（LPV）。血清流行病学研究表明，除了AGM血清外，相当一部分人类血清与该病毒的抗原发生反应。免疫沉淀 (IP) 和中和研究强调了间接免疫荧光测试中观察到的这种反应的特异性。 IP证明AGM和人血清在免疫荧光中与LPV抗原反应沉淀了.apprx的多肽。 40 千道尔顿。这些多肽仅在 LPV 感染的培养物中检测到。免疫荧光测试中高反应性的血清也能中和病毒感染性。因此，与 AGM-LPV 抗原性密切相关的病原体可能会感染部分人群。人类抗体反应的年龄分布表明，<30 岁的年龄组中出现反应的血清百分比较低。此后，.apprx。 30% 的血清表现出针对 LPV 抗原的抗体。与未选择的人类血清相比，接受传染性肝炎检测的患者血清的血清反应性略有增加。
A novel member of the papovavirus group was isolated from EBV[Epstein-Barr virus)-transformed African green monkey (AGM) B-lymphoblasts. The virus is characterized by its B-lymphotropic host range and was tentatively named lymphotropic papovavirus (LPV). Seroepidemiological studies revealed that, besides sera from AGM, a substantial proportion of human sera reacted with antigens of this virus. The specificity of this reaction observed in indirect immunofluorescence tests was underlined by immunoprecipitation (IP) and neutralization studies. IP demonstrated that AGM and human sera reacting in immunofluorescence with LPV antigens precipitated polypeptides of .apprx. 40 kilodaltons. Those polypeptides were detected only in LPV-infected cultures. Sera of high reactivity in immunofluorescence tests also neutralize viral infectivity. Thus, an agent antigenetically closely related to AGM-LPV may infect part of the human population. The age distribution of the human antibody response revealed that a low percentage of sera reacted in age groups < 30 yr. Thereafter, .apprx. 30% of all sera exhibited antibodies to LPV antigens. There was a slight increase in seroreactivity in sera from patients tested for infectious hepatitis when compared to non-selected human sera.