ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation.
ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation.
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DOI：
10.1038/cddis.2013.253
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发表时间：
2013-07-11
影响因子：
9
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中科院分区：
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血小板在人体中扮演着重要的角色，因为它具有止血、血栓形成和炎症等多种功能。血小板是由巨核细胞（MK）从造血干细胞分化而来，经过几个连续的阶段，包括MK谱系承诺、MK祖细胞增殖、MK分化和成熟、细胞凋亡和血小板释放。在分化过程中，细胞在骨髓中从成骨细胞生态位向血管生态位迁移，这一过程伴随着微环境中活性氧（ROS）依赖的氧化态变化，提示ROS能够以微环境依赖的方式明显影响血小板的生成和功能。本文的目的是揭示ROS在调节MK增殖、分化、成熟和血小板活化中的作用，从而为血小板产生的机制提供新的见解，从而可能导致新的治疗血小板减少和/或血栓形成的药物的开发。
Platelets have an important role in the body because of their manifold functions in haemostasis, thrombosis, and inflammation. Platelets are produced by megakaryocytes (MKs) that are differentiated from haematopoietic stem cells via several consecutive stages, including MK lineage commitment, MK progenitor proliferation, MK differentiation and maturation, cell apoptosis, and platelet release. During differentiation, the cells migrate from the osteoblastic niche to the vascular niche in the bone marrow, which is accompanied by reactive oxygen species (ROS)-dependent oxidation state changes in the microenvironment, suggesting that ROS can distinctly influence platelet generation and function in a microenvironment-dependent manner. The objective of this review is to reveal the role of ROS in regulating MK proliferation, differentiation, maturation, and platelet activation, thereby providing new insight into the mechanism of platelet generation, which may lead to the development of new therapeutic agents for thrombocytopenia and/or thrombosis.