Macular morphology following unilateral bevacizumab injection for retinopathy of prematurity: an OCT study
Macular morphology following unilateral bevacizumab injection for retinopathy of prematurity: an OCT study
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DOI：
10.1016/j.jaapos.2017.06.024
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发表时间：
2017-12-01
期刊：
影响因子：
1.6
通讯作者：
Tehrani, Nasrin N.
中科院分区：
文献类型：
--
作者：
Clark, Antony;Wright, Tom;Tehrani, Nasrin N.
该回顾性病例系列评估了单侧玻璃体内注射贝伐单抗 (IVB) 治疗单侧 1 型早产儿视网膜病变 (ROP) 对黄斑厚度和中心凹发育的影响。 7 名患有单侧 1 型 ROP 的婴儿仅在一只眼中接受玻璃体内注射贝伐单抗 0.625 mg/0.025 ml。为了确定黄斑厚度和中央凹结构发育是否受到治疗的影响，对治疗和未治疗的眼睛进行了谱域光学相干断层扫描。婴儿的平均胎龄为 25.3 +/- 0.3 周；平均出生体重，776 +/- 17.6 克。治疗的平均月经后年龄为 37.2 +/- 0.4 周。接受治疗的 3 只 (43%) 眼睛的中心凹发育正常，而未接受治疗的 5 只 (71%) 眼睛的中心凹发育正常。治疗和未治疗眼睛的平均中央凹厚度分别为270.1μm+/-19.6和253.0μm+/-27.2(P=0.15)。与其他眼睛相比，接受玻璃体内贝伐单抗治疗的眼睛的中心凹发育和厚度存在微小但不显着的差异。这项研究产生了重要的数据来检验以下假设：与未经治疗的另一只眼睛相比，接受 IVB 治疗的单侧 1 型 ROP 眼睛的中心凹厚度更大。
This retrospective case series assessed the influence of unilateral intravitreal bevacizumab (IVB) for unilateral type 1 retinopathy of prematurity (ROP) on macular thickness and foveal development. Seven infants with unilateral type 1 ROP were treated with intravitreal bevacizumab 0.625 mg/0.025 ml in one eye only. To determine whether macular thickness and fovea structural development were affected by treatment, spectral domain optical coherence tomography was performed on both treated and untreated eyes. The mean gestational age of infants was 25.3 +/- 0.3 weeks; the mean birth weight, 776 +/- 17.6 g. Treatment was given at a mean post menstrual age of 37.2 +/- 0.4 weeks. Foveal development was normal in 3 (43%) treated versus 5 (71%) untreated eyes. The mean central foveal thickness for treated and untreated eyes was 270.1 mu m +/- 19.6 and 253.0 mu m +/- 27.2 respectively (P = 0.15). There was small but nonsignificant difference in foveal development and thickness in eyes treated with intravitreal bevacizumab compared to fellow eyes. This study generates important data to test the hypothesis that foveal thickness is greater in unilateral type 1 ROP eyes treated with IVB compared to untreated fellow eyes.