The HHpred interactive server for protein homology detection and structure prediction.

The HHpred interactive server for protein homology detection and structure prediction.
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用于蛋白质同源性检测和结构预测的 HHpred 交互式服务器。

DOI:
10.1093/nar/gki408
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发表时间:
2005-07-01
影响因子:
14.9
通讯作者:
Lupas, AN
Lupas, AN
中科院分区:
生物学2区
文献类型:
--
作者:
Söding, J;Biegert, A;Lupas, AN

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HHpred是一个用于远程蛋白质同源性检测和结构预测的快速服务器,并且是第一个实现轮廓隐马尔可夫模型(HSPs)的成对比较的服务器。它允许搜索广泛的数据库,如PDB,SCOP,Pfam,SMART,COG和CDD。它接受单个查询序列或多个比对作为输入。在短短几分钟内,它以类似于PSI-BLAST的用户友好格式返回搜索结果。搜索选项包括局部或全局比对和二级结构相似性评分。HHpred可以产生成对查询-模板比对,查询与从搜索结果中选择的一组模板的多重比对,以及由MODELLER软件从这些比对计算的3D结构模型。提供详细的帮助工具。作为示范,我们分析了SpoVT的序列,SpoVT是枯草芽孢杆菌的转录调节因子。HHpred可以访问。
HHpred is a fast server for remote protein homology detection and structure prediction and is the first to implement pairwise comparison of profile hidden Markov models (HMMs). It allows to search a wide choice of databases, such as the PDB, SCOP, Pfam, SMART, COGs and CDD. It accepts a single query sequence or a multiple alignment as input. Within only a few minutes it returns the search results in a user-friendly format similar to that of PSI-BLAST. Search options include local or global alignment and scoring secondary structure similarity. HHpred can produce pairwise query-template alignments, multiple alignments of the query with a set of templates selected from the search results, as well as 3D structural models that are calculated by the MODELLER software from these alignments. A detailed help facility is available. As a demonstration, we analyze the sequence of SpoVT, a transcriptional regulator from Bacillus subtilis. HHpred can be accessed at .
DOI: 10.1002/prot.20044
发表时间: 2004-05-01
影响因子: 2.9
作者:
Kihara, D;Jeffrey, S
通讯作者: Jeffrey, S
DOI: 10.1093/nar/gkg154
发表时间: 2003-01-15
影响因子: 14.9
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通讯作者: Panchenko, AR
DOI: 10.1073/pnas.0405913101
发表时间: 2004-10-05
影响因子: 11.1
作者:
Rand, TA;Ginalski, K;Wang, XD
通讯作者: Wang, XD
DOI: 10.1093/nar/gki213
发表时间: 2005
影响因子: 14.9
作者:
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DOI: 10.1093/bioinformatics/bti125
发表时间: 2005-04-01
期刊: BIOINFORMATICS
影响因子: 5.8
作者:
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通讯作者: Söding, J