A tetracycline-based histomorphometric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism.
A tetracycline-based histomorphometric evaluation of bone resorption and bone turnover in hyperthyroidism and hyperparathyroidism.
复制标题
基于四环素的组织形态学评估甲状腺功能亢进症和甲状旁腺功能亢进症的骨吸收和骨转换。
作者：
L. Mosekilde;F. Melsen
以前在甲状腺功能亢进症中发现的骨吸收增加可能是由甲状腺激素对骨细胞的直接刺激作用或对循环甲状旁腺激素的敏感性增加引起的。为了揭示骨吸收细胞对过量甲状旁腺激素和过量甲状腺激素反应的定性差异，对25例甲状旁腺功能亢进和40例甲状腺功能亢进患者的髂嵴活检进行了四环素双标记后的组织形态计量学分析。甲状旁腺和甲状腺激素的主要靶细胞不同。甲状旁腺激素刺激骨细胞性骨溶解，增加骨小梁和皮质骨的骨吸收表面。骨吸收不活跃。甲状腺激素对骨细胞没有影响，但增加了骨小梁和皮质骨的骨吸收表面，在皮质骨中具有明显的优势。骨吸收活跃，随后皮质骨和松质骨显著丢失。这些发现支持了这样的假设，即甲状腺功能亢进症的骨吸收增加是由甲状腺激素的直接刺激作用引起的。
Increased bone, resorption previously found in hyperthyroidism might be caused by a direct stimulating effect of thyroid hormone(s) on bone cells or by an increased sensitivity to circulating parathyroid hormone. In order to disclose qualitative differences in the response of bone resorbing cells to excess parathyroid hormone and excess thyroid hormone(s), histomorphometric analysis of iliac crest biopsies was performed in 25 hyperparathyroid and 40 hyperthyroid patients after tetracycline double-labelling. The main target cells for parathyroid and thyroid hormones were different. Parathyroid hormone stimulated osteocytic osteolysis and increased osteoclastic resorption surfaces equally in trabecular and cortical bone. The osteoclastic resorption was inactive. Thyroid hormone(s) had no effect on osteocytes but increased the osteoclastic resorption surfaces in trabecular and cortical bone, with a pronounced preponderance in cortical bone. The osteoclastic resorption was active and followed by a significant loss of both cortical and trabecular bone. The findings support the assumption that increased bone resorption in hyperthyroidism is caused by a direct stimulating effect of thyroid hormone(s).