Enzyme Responsive Inverse Opal Hydrogels
Enzyme Responsive Inverse Opal Hydrogels
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DOI：
10.1002/marc.201900555
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发表时间：
2020-01-31
影响因子：
4.6
通讯作者：
Kilian, Kristopher A.
中科院分区：
文献类型：
--
作者：
Pei, Yi;Molley, Thomas G.;Kilian, Kristopher A.
自然界中的结构色是由纳米和微结构界面控制的，从而产生光子带隙。本研究提出了一种基于聚合物反蛋白石的仿生光学材料，该材料对酶活性有响应。聚合物胶体提供了一个模板，其中丙烯酰功能化聚乙二醇是集成的；胶体的溶解导致水凝胶反蛋白石，可以使用转移印刷平版图案。将酶底物掺入孔洞内提供了一种材料，该材料通过光学性质的变化对蛋白酶的存在作出反应。
Structured color in nature is controlled by nano- and micro-structured interfaces giving rise to a photonic bandgap. This study presents a biomimetic optical material based on polymeric inverse opals that respond to enzyme activity. Polymer colloids provide a template in which acryloyl-functionalized poly(ethylene glycol) is integrated; dissolution of the colloids leads to a hydrogel inverse opal that can be lithographically patterned using transfer printing. Incorporating enzyme substrates within the voids provides a material that responds to the presence of proteases through a shift in the optical properties.