Triterpene constituents from the stem bark of Pinus luchuensis and their DNA topoisomerase II inhibitory effect
Triterpene constituents from the stem bark of Pinus luchuensis and their DNA topoisomerase II inhibitory effect
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DOI：
10.1055/s-2001-17360
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发表时间：
2001-10-01
期刊：
影响因子：
2.7
通讯作者：
Tanaka, R
中科院分区：
文献类型：
--
作者：
Wada, S;Iida, A;Tanaka, R
从琉球松茎皮中分离得到九种羊毛甾烷和锯齿烷型三萜化合物，其中包括两种未知化合物。根据光谱证据，这些新化合物被定性为 3-oxolanost-9(11)-ene-24S,25-diol (1) 和 29-acetoxy-3 beta -methoxyserrat-14-en-21 alpha -ol (2)。测试了其中一些三萜对 DNA 拓扑异构酶 11 活性的抑制作用。化合物1显示出稍弱的抑制活性，IC50值为186μM。
Nine lanostane and serratane-type triterpenes including two unknown compounds were isolated from the stem bark of Pinus luchuensis. These new compounds were characterized as 3-oxolanost-9(11)-ene-24S,25-diol (1) and 29-acetoxy-3 beta -methoxyserrat-14-en-21 alpha -ol (2) on the basis of spectroscopic evidence. Some of these triterpenes were tested for the inhibitory effect on DNA topoisomerase 11 activity. Compound 1 showed a slightly less potent inhibitory activity with an IC50 value of 186 muM.