Ethnic differences in carotid wall thickness - The Insulin Resistance Atherosclerosis Study
Ethnic differences in carotid wall thickness - The Insulin Resistance Atherosclerosis Study
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DOI：
10.1161/01.str.27.10.1744
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发表时间：
1996-10-01
期刊：
影响因子：
8.3
通讯作者：
Haffner, SM
中科院分区：
文献类型：
--
作者：
DAgostino, RB;Burke, G;Haffner, SM
背景和目的 在美国成年人中观察到心血管疾病 (CVD) 发病率和死亡率存在种族差异。然而，关于美国非西班牙裔白人、西班牙裔和黑人临床前动脉粥样硬化指数（例如颈动脉壁内膜中层厚度（IMT））差异的数据很少。本研究旨在确定颈动脉壁 IMT 是否存在种族差异。方法在胰岛素抵抗动脉粥样硬化研究中，使用 B 型超声对 1020 名非糖尿病参与者的颈内动脉 (ICA) IMT 和颈总动脉 (CCA) IMT（动脉粥样硬化指数）进行评估，该研究旨在检查胰岛素抵抗与颈动脉粥样硬化之间的关联。该研究包括 281 名黑人、329 名西班牙裔和 410 名年龄在 40 至 69 岁之间的非西班牙裔白人。 结果 黑人的 CCA IMT 显着高于非西班牙裔白人（865 比 808 μm）；在调整主要 CVD 危险因素和胰岛素敏感性后，这一结果仍然显着（864 与 823 μm）。黑人和非西班牙裔白人之间的 ICA IMT 没有显着差异。西班牙裔人的 CCA IMT 显着低于非西班牙裔白人（749 与 776 μm），并且在调整传统心血管危险因素和胰岛素敏感性（750 与 778 μm）后，这些差异仍然显着。非西班牙裔白人和西班牙裔之间的 ICA IMT 没有显着差异。结论 我们的结论是，在非糖尿病受试者中，CCA 存在种族差异，但 ICA IMT 不存在种族差异。 IMT 的这些差异是动脉粥样硬化的指标，是一种无创测量方法，与一些临床终点数据一致。这些差异可能与观察到的美国主要种族群体中 CVD 发病率和死亡率的差异有关。
Background and Purpose Ethnic differences in cardiovascular disease (CVD) morbidity and mortality have been observed in US adults. However, little data exist on differences in indices of preclinical atherosclerosis such as carotid wall intima-media thickness (IMT) for US non-Hispanic whites, Hispanics, and blacks. This study was undertaken to determine whether there were ethnic differences in carotid wall IMT.Methods Internal carotid artery (ICA) IMT and common carotid artery (CCA) IMT, indices of atherosclerosis, were assessed with the use of B-mode ultrasound in 1020 nondiabetic participants in the Insulin Resistance Atherosclerosis Study, a multicenter study designed to examine the association between insulin resistance and carotid atherosclerosis. The study included 281 blacks, 329 Hispanics, and 410 non-Hispanic whites aged 40 to 69 years.Results Blacks had significantly greater CCA IMT than non-Hispanic whites (865 versus 808 mu m); this remained significant after adjustment for major CVD risk factors and insulin sensitivity (864 versus 823 mu m). There were no significant differences in ICA IMT between blacks and non-Hispanic whites. Hispanics had significantly lesser CCA IMT than non-Hispanic whites (749 versus 776 mu m), and these differences remained significant after adjustment for traditional cardiovascular risk factors and insulin sensitivity (750 versus 778 mu m). There were no significant differences in ICA IMT between non-Hispanic whites and Hispanics.Conclusions We conclude that ethnic differences exist in CCA but not in ICA IMT in nondiabetic subjects. These differences in IMT, which are indicators of atherosclerosis, are a noninvasive measure that is consistent with some of the data on clinical end points. These differences may be associated with the observed differences in CVD morbidity and mortality among major ethnic groups in the United States.