Central inhibitory action of prostaglandin E2 on gastric secretion in the rat.
Central inhibitory action of prostaglandin E2 on gastric secretion in the rat.
复制标题
前列腺素E2对大鼠胃分泌的中枢抑制作用。
DOI：
10.1016/0014-2999(83)90472-7
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发表时间：
1983
影响因子：
5
通讯作者：
J. Puurunen
中科院分区：
文献类型：
--
作者：
J. Puurunen
本文研究了前列腺素E_2（PGE_2）对清醒幽门结扎大鼠胃分泌的中枢作用。结果表明，静脉注射1-10 μg/g PGE_2可剂量依赖性地减少胃酸、胃蛋白酶和胃液的排出量，而皮下注射则需要30-300 μg/g PGE_2才能抑制胃酸、胃蛋白酶和胃液的排出。静脉注射400 μg吲哚美辛（一种前列腺素生物合成的强效抑制剂）可增强胃分泌，但肌肉注射则无此作用。提示PGE_2对清醒大鼠胃分泌有中枢抑制作用。抑制，PGE 2可能作为抑制性调节剂参与胃分泌的中枢控制，值得进一步关注。
The central nervous system action of prostaglandin E2(PGE2) on gastric secretion was studied in consious pylorus-ligated rats. It was found that 1–10 μg og PGE2given i.c.v. reduced the gastric output of acid, pepsin and fluid in a dose-dependent manner whereas 30–300 μg was required for inhibition when given subcutaneously. Given i.c.v. 400 μg of indomethacin, a potent inhibitor of prostaglandin biosynthesis, enhanced gastric secretion but not when given intramuscularly. It is concluded that PGE2has a central inhibitory action on gastric secretion in conscious rats. Inhibition, the possibility that PGE2may be involved as inhibitory modulator in the central control of gastric secretion warrants further attention.