AKR1B10 in usual interstitial pneumonia: Expression in squamous metaplasia in association with smoking and lung cancer
AKR1B10 in usual interstitial pneumonia: Expression in squamous metaplasia in association with smoking and lung cancer
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DOI：
10.1016/j.prp.2006.12.012
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发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Fukayama, Masashi
中科院分区：
文献类型：
--
作者：
Li, Chih-Ping;Goto, Akiteru;Fukayama, Masashi
在普通型间质性肺炎(UIP)患者中，肺癌(LC)的发病率显著增加，吸烟是其叠加危险因素。AKRIB10(醛酮还原酶IB10)在吸烟者的肺鳞癌和腺癌中经常过表达。为探讨AKRIB10在与吸烟相关的UIP肺癌发生中的作用，应用AKRIB10免疫组织化学方法对13例有LC的UIP、13例非LC的UIP和30例非UIP LC进行了检测。AKRIB10免疫反应局限于UIP的蜂窝状病变和LC的肿瘤细胞中的鳞状化生。UIP合并LC组鳞状上皮化生灶AKR1B10阳性率(24/36，67%)明显高于非LC组(16/44，37%)(P
The incidence of lung cancer (LC) is markedly increased among patients with usual interstitial pneumonia (UIP), and tobacco smoking is its superimposed risk factor. AKRIB10 (aldo-keto reductase IB10) is frequently overexpressed in pulmonary squamous cell carcinoma and adenocarcinoma in smokers. To investigate the role of AKRIB10 in the pulmonary carcinogenesis in UIP with correlation to tobacco smoking, we examined 13 UIP cases with LC, 13 UIP cases without LC, and 30 cases of non-UIP LC using AKRIB10 immunohistochemistry. AKRIB10 immunoreactivity was confined to squamous metaplasia in honeycomb lesions of UIP and neoplastic cells of LC. Squamous metaplastic foci showed AKR1B10 immunoreactivity more frequently in UIP with LC (24/36 foci, 67%) than in UIP without LC (16/44 foci, 37%) (P