Dominant-negative PKC-ε impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini
Dominant-negative PKC-ε impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini
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DOI：
10.1152/ajpcell.00546.2004
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发表时间：
2005-10-01
影响因子：
5.5
通讯作者：
Hamm-Alvarez, SF
中科院分区：
文献类型：
--
作者：
Jerdeva, GV;Yarber, FA;Hamm-Alvarez, SF
我们研究了蛋白激酶C - ε（PKC - ε）在卡巴胆碱刺激的重组兔泪腺腺泡细胞胞吐过程中顶端肌动蛋白重塑中的作用。在肌动蛋白丝结合试验中，泪腺腺泡PKC - ε与肌动蛋白丝共沉降。用卡巴胆碱（100 μM，2 - 15分钟）刺激腺泡显著（P（此处原句似乎不完整，可能影响对整体意思的准确理解）
We investigated the involvement of PKC-epsilon in apical actin remodeling in carbachol-stimulated exocytosis in reconstituted rabbit lacrimal acinar cells. Lacrimal acinar PKC-epsilon cosedimented with actin filaments in an actin filament binding assay. Stimulation of acini with carbachol (100 mu M, 2-15 min) significantly (P