Light-chain nephropathy in patient with renal carcinoma.
Light-chain nephropathy in patient with renal carcinoma.
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肾癌患者的轻链肾病。
DOI：
10.1136/bmj.283.6287.339
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发表时间：
1981
影响因子：
--
通讯作者：
Q. Maggiore
中科院分区：
文献类型：
--
作者：
G. Enia;S. Maringhini;A. L'Abbate;C. Zoccali;Q. Maggiore
副肿瘤综合征通常与肾实质肿瘤有关。本文报告一例肾细胞癌合并κ链肾病。患者为60岁男性，有肾小管功能障碍，表现为血清尿酸盐和磷酸盐浓度低。在血清和尿液中均发现κ链，但未发现β链。检查显示为透明细胞癌，患者接受了根治性肾切除术。术后2年，血清磷酸盐和尿酸盐浓度恢复正常，血清或尿液中检测不到κ链。缺乏β链表明轻链蛋白尿是由于M组分的过度产生，而手术后κ链的消失表明肾肿瘤与M组分的过度产生之间存在因果关系。
Paraneoplastic syndromes are often associated with renal parenchymal tumours. This report describes a case of renal-cell carcinoma with kappa-chain nephropathy. The patient, a 60-year-old man, had renal tubular dysfunction, shown by low serum concentrations of urate and phosphate. Kappa-chains were found in both serum and urine, but no lambda-chains were found. Investigations showed a clear-cell carcinoma, and the patient underwent a radical nephrectomy. Two years after operation serum phosphate and urate concentrations had returned to normal, and kappa-chains were undetectable in serum or urine. The absence of lambda-chains indicates that the light-chain proteinuria was due to overproduction of the M component, and the disappearance of kappa-chains after the operation suggests a causal relation between the renal tumour and the overproduction of the M component.