Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons.
Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons.
复制标题
神经元胞吞作用与胞吐作用耦合的分子机制
DOI：
10.3389/fnmol.2017.00047
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发表时间：
2017
影响因子：
4.8
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Xie Z;Long J;Liu J;Chai Z;Kang X;Wang C
神经元通讯和大脑功能主要取决于神经传递的基本生物学事件，包括用于神经递质释放的突触前小泡（SV）的胞吐作用和随后用于 SV 恢复的内吞作用。神经递质通过 Ca2+- 和 SNARE 依赖的 SV 与突触前质膜的融合来释放。胞吐作用后，立即发生内吞作用，以恢复 SV 膜和融合机制以进行局部回收，从而维持突触结构和持续神经传递的稳态。除了一般的内吞机制之外，最近的研究还揭示了 SNARE 蛋白（突触短蛋白、SNAP25 和突触蛋白）、突触素、Ca2+/钙调蛋白和突触结合蛋白家族成员（Syt1、Syt4、Syt7 和 Syt11）参与神经元外吞作用的平衡和紧密耦合。在这里，我们概述了了解这些神经元特异性适配器如何协调以确保神经传递过程中精确有效的内吞作用的最新进展。
Neuronal communication and brain function mainly depend on the fundamental biological events of neurotransmission, including the exocytosis of presynaptic vesicles (SVs) for neurotransmitter release and the subsequent endocytosis for SV retrieval. Neurotransmitters are released through the Ca2+- and SNARE-dependent fusion of SVs with the presynaptic plasma membrane. Following exocytosis, endocytosis occurs immediately to retrieve SV membrane and fusion machinery for local recycling and thus maintain the homeostasis of synaptic structure and sustained neurotransmission. Apart from the general endocytic machinery, recent studies have also revealed the involvement of SNARE proteins (synaptobrevin, SNAP25 and syntaxin), synaptophysin, Ca2+/calmodulin, and members of the synaptotagmin protein family (Syt1, Syt4, Syt7 and Syt11) in the balance and tight coupling of exo-endocytosis in neurons. Here, we provide an overview of recent progress in understanding how these neuron-specific adaptors coordinate to ensure precise and efficient endocytosis during neurotransmission.