Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer.
Proliferative activity of rectal mucosa and soluble fecal bile acids in patients with normal colons and in patients with colonic polyps or cancer.
复制标题
正常结肠患者和结肠息肉或癌症患者的直肠粘膜和可溶性粪便胆汁酸的增殖活性。
DOI：
10.1016/0304-3835(88)90023-7
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发表时间：
1988
期刊：
影响因子：
9.7
通讯作者：
W. Bruce
中科院分区：
文献类型：
--
作者：
J. Stadler;Ka Sing Yeung;R. Furrer;N. Marcon;H. S. Himal;W. Bruce
直肠活检和粪便采集来自胃肠病学诊所结肠镜检查前的连续34名门诊患者。随后，14人被发现没有结肠病理，13人有腺瘤性息肉，(其中3人有结肠癌病史)，7人被诊断为结肠癌。在早期的研究中，肿瘤患者的氚胸苷标记指数高于无病理患者(7.9%vs.5.8%，P=0.06)。结肠肿瘤患者的粪便水提物中去氧胆酸和石胆酸水平也显著升高(P=0.005)。这项研究表明，这些生化指标可能预示着患结肠癌的风险。
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous history of colon cancer) and 7 were diagnosed with colon cancer. In confirmation of earlier studies the tritiated thymidine labelling index was higher in patients with tumors than in those without pathology (7.9% vs. 5.8% withP= 0.06). The patients with colonic tumors also had significantly higher levels of deoxycholic acid (P= 0.01) and lithocholic acid (P= 0.005) in the aqueous extract of their feces. This study shows that these biochemical measures may indicate colon cancer risk.