Comparison of liver tumor frequencies after intermittent oral administration of different doses of N-nitrosopyrrolidine in Sprague-Dawley rats.
Comparison of liver tumor frequencies after intermittent oral administration of different doses of N-nitrosopyrrolidine in Sprague-Dawley rats.
复制标题
Sprague-Dawley大鼠间歇口服不同剂量N-亚硝基吡咯烷后肝脏肿瘤发生率的比较。
DOI：
10.1016/0304-3835(85)90175-2
复制
发表时间：
1985
期刊：
影响因子：
9.7
通讯作者：
D. Schmähl
中科院分区：
文献类型：
--
作者：
A. Hoos;M. Habs;D. Schmähl
对400只Sprague-Dawley大鼠经口给予N-亚硝基吡咯烷（N-Pyr）。另一组80只大鼠作为未处理对照组。有5个单独的组，其中比较了不同给药期和不同未给药间隔的影响。个体剂量对应于0.0、1.0、1.2和2.0 mg/kg/天。总剂量（试验开始后600天）始终为600 mg/kg N-Pyr。在各个N-Pyr处理组中观察到肝肿瘤的发生率显著不同。这些发现支持了这样的假设，即肿瘤风险不仅取决于致癌物质的个体和总剂量，而且还与年龄有关。
N-Nitrosopyrrolidine (N-Pyr) was administered orally to 400 Sprague-Dawley rats. An additional group of 80 rats served as an untreated control. There were 5 individual groups in which the effects of different periods of dosing and varying intervals without treatment were compared. Individual doses corresponded to 0.0, 1.0, 1.2 and 2.0 mg/kg per day. The total dose (600 days after the start of the trial) always amounted to 600 mg/kg N-Pyr. Significantly different incidences of liver tumors were observed in the individual N-Pyr-treated groups. The findings support the assumption that tumor risks not only depend on individual and total doses of the administered carcinogen, but are also an age-related function.