Application of 4,5-O,N-oxazolidinone protected thiophenyl sialosyl donor to the synthesis of α-sialosides
Application of 4,5-O,N-oxazolidinone protected thiophenyl sialosyl donor to the synthesis of α-sialosides
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DOI：
10.1016/j.tetlet.2006.12.061
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发表时间：
2007-02-12
影响因子：
1.8
通讯作者：
De Meo, Cristina
中科院分区：
文献类型：
--
作者：
Farris, Michael D.;De Meo, Cristina
报道了一种新型恶唑烷酮唾液酸供体的合成。反式稠环的引入增强了用于合成α-唾液酸糖苷的糖基化反应中的反应性和立体选择性。恶唑烷酮环也可以在碱性条件下除去，得到脱保护的胺，其可以进一步官能化。(c)2006爱思唯尔有限公司保留所有权利。
The synthesis of a novel oxazolidinone sialosyl donor is reported. The introduction of a trans-fused ring enhances reactivity and stereoselectivity in glycosylation reactions for the synthesis of alpha-sialosides. The oxazolidinone ring can also be removed under basic conditions to afford the deprotected amine, which can be further functionalized. (c) 2006 Elsevier Ltd. All rights reserved.