Effect of mannitol on cerebrospinal fluid pressure. The actions of hypertonic mannitol solutions and of urea compared.
Effect of mannitol on cerebrospinal fluid pressure. The actions of hypertonic mannitol solutions and of urea compared.
复制标题
甘露醇对脑脊液压力的影响。
DOI：
10.1001/archneur.1961.00450080082009
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发表时间：
1961
影响因子：
--
通讯作者：
N. Chater
中科院分区：
文献类型：
--
作者：
B. L. Wise;N. Chater
在寻找安全有效的高渗溶液以降低脑脊液（CSF）压力和减少脑体积的过程中，已经测试了许多药物。1-4最近，30%的尿素溶液已被用于此目的。5甘露醇高渗溶液已广泛用于动物和人类6-8，没有毒性证据。甘露糖主要局限于细胞外空间，代谢很少，排泄相当迅速。9-10因此，从理论上讲，静脉注射高渗甘露醇溶液可能是降低CSF压力和减少脑体积的极好药物。方法犬静脉注射戊巴比妥钠（25 mg/kg）麻醉，根据需要追加麻醉药。插入气管内导管并连接到呼吸器上。在所有实验中控制呼吸。在小脑延髓池中的一根针连接到一个斯坦森应变计压力计，
In the search for a safe and effective hypertonic solution to lower cerebrospinal fluid (CSF) pressure and decrease brain bulk, many agents have been tested. 1-4 Recently, 30% urea solution has been utilized for this purpose. 5 Hypertonic solutions of mannitol have been used extensively in animals and humans 6-8 without evidence of toxicity. Mannitol is confined mainly to the extracellular space, is metabolized little if at all, and is excreted fairly rapidly. 9-10 Thus, on theoretical grounds, it appeared that hypertonic mannitol solution, administered intravenously, might be an excellent agent for lowering CSF pressure and reducing brain bulk. Methods Dogs were anesthetized by the intravenous administration of sodium pentobarbital (25 mg/kg), and supplemental anesthetic as needed. An endotracheal tube was inserted and attached to a respirator. Respiration was controlled throughout all experiments. A needle in the cisterna magna was connected to a Statham strain gauge manometer, and cerebrospinal fluid