Regulation of 1lβ-Hydroxysteroid Dehydrogenase Activity in the Baboon Placenta by Estrogen*
Regulation of 1lβ-Hydroxysteroid Dehydrogenase Activity in the Baboon Placenta by Estrogen*
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雌激素对狒狒胎盘中 1lβ-羟基类固醇脱氢酶活性的调节*
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
G. Pepe
中科院分区：
文献类型：
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作者：
S. Baggia;E. Albrecht;G. Pepe
我们以前已经证明，在体内经胎盘皮质醇（F）-可的松（E）代谢从妊娠中期的优先还原（E到F）到足月的氧化（F到E）的变化，在雌激素的产生或作用被阻断的狒狒中并没有发生。此外，由于狒狒给予雄烯二酮（Δ4A）增加了妊娠中期雌二醇（E2）的产生，并诱导了与足月时相似的F-E代谢模式，因此我们认为雌激素调节胎盘F-E相互转换。本研究旨在确定雌激素是否调节胎盘11β-羟基类固醇脱氢酶（11βHSD）催化F氧化为E的活性。在妊娠第100天（n = 10）和第165天（n = 10）从未处理的狒狒（术语=第184天）获得胎盘，在第100天从妊娠第70-100天之间用Δ4A处理的动物（n = 7）获得胎盘，在第165天从通过胎儿切除术降低胎盘雌激素的动物（n = 5）获得胎盘。
We have previously shown that the change in transuteroplacental cortisol (F)-cortisone (E) metabolism in vivo from preferential reduction (E to F) at midgestation to oxidation by term (F to E) does not occur in baboons in which the production or action of estrogen have been blocked. Moreover, because the administration of androstenedione (Δ4A) to baboons increased estradiol (E2) production at midgestation and induced a pattern of F-E metabolism similar to that at term, we suggested that estrogen regulates placental F-E interconversion. The present study was designed to ascertain whether estrogen regulates the activity of the placental 11β-hydroxysteroid dehydrogenase (11βHSD) enzyme catalyzing the oxidation of F to E. Placentas were obtained on day 100 (n = 10) and day 165 (n = 10) of gestation (term = day 184) from untreated baboons, on day 100 from animals (n = 7) treated with Δ4A between days 70-100 of gestation, and on day 165 from animals in which placental estrogen was decreased by fetectomy (n = 5)...