Genetic variation in EEG activity during sleep in inbred mice
Genetic variation in EEG activity during sleep in inbred mice
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DOI：
10.1152/ajpregu.1998.275.4.r1127
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发表时间：
1998-10-01
影响因子：
2.8
通讯作者：
Tafti, M
中科院分区：
文献类型：
--
作者：
Franken, P;Malafosse, A;Tafti, M
通过对6个近交系小鼠自发节律性脑电(EEG)活动的定量分析，评估了EEG活动的遗传变异。获得了异相睡眠(PS)、慢波睡眠(SWS)和清醒状态下的平均频谱脑电曲线(0-25 Hz)。在PS和SWS期间，theta峰值频率都发现了非常显著的基因型特异性变异，这强烈地表明存在一个具有主要影响的基因。在探索行为和睡眠中，theta峰值频率的应变分布不同。在SWS中，Delta(1-4 HZ)和Sigma(11-15)功率对脑电的相对贡献因基因型而异，两个频段的功率均呈负相关。此外，还利用4-S分辨率分析了状态转换时的脑电动力学。PS的开始，而不是觉醒的开始，是在高频(>；11赫兹)功率的明显峰值之前。这些发现从节律产生的神经生理学机制以及脑干网状激活系统对节律的控制和调节方面进行了讨论。
The genetic variation in spontaneous rhythmic electroencephalographic (EEG) activity was assessed by the quantitative analysis of the EEG in six inbred mice strains. Mean spectral EEG profiles (0-25 Hz) over 24 h were obtained for paradoxical sleep (PS), slow-wave sleep (SWS), and wakefulness. A highly significant genotype-specific variation was found for theta peak frequency during both PS and SWS, which strongly suggests the presence of a gene with a major effect. The strain distribution of theta peak frequency during exploratory behavior differed from that during sleep. In SWS, the relative contributions of delta (1-4 Hz) and sigma (11-15) power to the EEG varied with genotype and power in both frequency bands was negatively correlated. In addition, the EEG dynamics at state transitions were analyzed with a 4-s resolution. The onset of PS, but not that of wakefulness, was preceded by a pronounced peak in high-frequency (>11 Hz) power. These findings are discussed in terms of the neurophysiological mechanisms underlying rhythm generation and their control and modulation by the brain stem reticular-activating system.