Dopamine and senescence in Drosophila melanogaster
Dopamine and senescence in Drosophila melanogaster
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DOI：
10.1016/s0197-4580(99)00109-8
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发表时间：
2000-01-01
影响因子：
4.2
通讯作者：
Mayer, A
中科院分区：
文献类型：
--
作者：
Neckameyer, WS;Woodrome, S;Mayer, A
5天大的雄性黑腹果蝇，当接触到2小时大的雄性果蝇时，会进行求爱仪式；这种行为的强度和持续时间随着时间的推移而迅速减少。老年雄性对年轻雄性发出的吸引信号的适应能力是一种多巴胺能调节的、依赖经验的行为修正，随着年龄的增长而消失。多巴胺耗竭的雌性对交配表现出更强的抵抗力；与5-15日龄的雌性相比，20日龄的雌性更倾向于避免交配。在衰老过程中观察到的这些多巴胺能调节行为的变化与全身多巴胺水平的下降是平行的。使用针对果蝇酪氨酸羟化酶的抗体对成人大脑进行免疫细胞化学分析，以显示儿茶酚胺能细胞体随着年龄的增长而增加。这些结果表明，多巴胺能调节行为的缺陷可能是衰老大脑退行性变化的结果。(C) 2000 Elsevier Science Inc.；版权所有。
Five-day-old Drosophila melanogaster males, when exposed to 2-h-old males, will perform courtship rituals; the intensity and duration of this behavior rapidly diminishes with time. The ability of the older males to habituate to the attractive signals given off by the younger males is a dopaminergic-modulated experience-dependent modification of behavior that is abolished with increasing age. Dopamine-depleted females show increased resistance to copulation; 20-day-old females demonstrated an increase in copulation avoidance compared with younger (5-15-day-old) females. These changes in dopaminergic-modulated behaviors observed during aging parallel declines in whole body levels of dopamine. Immunocytochemical analysis of adult brains using an antibody raised against Drosophila tyrosine hydroxylase to visualize catecholaminergic cell bodies revealed increased degeneration of the cell bodies with aging. These results suggest that the deficits seen in dopaminergic-modulated behaviors may arise as a consequence of degenerative changes within the aging brain. (C) 2000 Elsevier Science Inc. All rights reserved.